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| Titel: |
Vision and visual plasticity in ageing mice |
| Auteur: |
Lehmann, Konrad Schmidt, Karl-Friedrich Löwel, Siegrid |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 30 (2012) nr. 2 pagina's 161-178 |
| Jaar: |
2012-02-20 |
| Inhoud: |
Purpose: Little is known about neuronal changes during ageing in the visual system of mice which are increasingly being used as animal models for human visual disorders. Methods and results: Measuring the optomotor response to moving gratings, visual acuity of C57BL/6-mice was 0.39 cycles/degree (cyc/deg) until 12 months of age and declined to 0.27 cyc/deg (by 30%) at 26 months. In the visual water task, a cortex-dependent task based on visual discrimination learning, visual acuity remained stable at 0.58 cyc/deg up to 21 months and then declined to 0.48 cyc/deg (by 19%) at 27 months. Visual cortical activity recorded by optical imaging declined by 33% between seven and 23 months of age. After monocular deprivation and daily testing of the optomotor response, visual acuity of the open eye increased by 29% in 4 to 7-month-old animals, while the increase was only 13% in 23-month-old mice. Interestingly, interindividual variability generally increased with age, so that some 23-month-old mice retained visual acuity and interocular plasticity like 4 or 7-month-old animals. Conclusions: In summary, reduced visual function was accompanied by a reduction of both visual cortical responses and interocular plasticity indicating a central nervous system component in age-related vision loss in mice. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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