|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 10 van 12 gevonden artikelen
| Titel: |
Recovery of visual evoked potentials after regeneration of cut retinal ganglion cell axons within the ascending visual pathway in adult rats |
| Auteur: |
Peter Heiduschka Dietmar Fischer Solon Thanos |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 23 (2005) nr. 5-6 pagina's 303-312 |
| Jaar: |
2005-12-05 |
| Inhoud: |
Purpose: Following optic nerve damage, retinal ganglion cells (RGCs) fail to regenerate their axons and soon undergo apoptosis. However, many RGCs survive axotomy and regenerate lengthy axons after a lens injury (LI). If the cut optic nerve is re-sutured, RGC axons grow into the distal part of the optic nerve and reach their natural targets within the thalamus and midbrain. In this study, we check time-dependence and extent of restoration of flash visual evoked potentials (FVEPs) to examine the functional relevance of the regenerated retinogeniculate pathway. Methods: The optic nerve in adult rats was cut and re-sutured. The lens was injured transsclerally using a pointed glass capillary. FVEPs were measured starting at the time point of surgery, and then repeatedly up to an age of several months. Results: Detectable FVEPs appeared approximately ten weeks after the surgery, and their amplitudes increased during the next months to reach eventually 15-40% of their values before surgery. Conclusions: Partial restoration of FVEPs indicates that some regenerating RGC axons have "bridged" the distance between the eye and the central targets forming a functional re-connection of the corresponding RGC with thalamic target neurones to elicit recordable activation of the visual cortex |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 12 gevonden artikelen
| << vorige | volgende >> |