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| Titel: |
Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors |
| Auteur: |
S.K. Schiemanck M.W.M. Post G. Kwakkel Th.D. Witkamp L.J. Kappelle A.J.H. Prevo |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 23 (2005) nr. 3-4 pagina's 257-263 |
| Jaar: |
2005-08-04 |
| Inhoud: |
Purpose: Previous studies investigating relationships between stroke lesion volume and outcome were restricted to short follow-up periods (3-6 months) and outcome measures of stroke severity and activities only, whereas functional improvement has been found to extend far beyond six months. Therefore, this study investigated relationships between infarct volume and a broad range of outcomes of stroke survivors at a long follow-up period. Methods: Correlations between lesion volumes (determined by conventional MRI scans in the second week post-stroke) and outcomes after one year of 75 first-ever ischemic stroke survivors were investigated. Results: Moderate Spearman Rank correlation coefficients were found between lesion volume and motor impairment (Motricity Index (MI): −0.43, p < 0.01; Fugl Meyer Motor Assessment Scale (FM): −0.43; p < 0.01). Correlation coefficients with activities of daily living were moderate but low associated with Barthel Index (r_s = 0.30; p < 0.01), modified Rankin Scale (r_s = 0.39; p < 0.01) and Frenchay Activities Index (r_s = −0.35; p < 0.01). Lesion volume had a significant but low association (r_s = 0.27; p = 0.02) with patient's health status measured with Sickness Impact Profile 68 (SIP68)) and a moderate correlation with well-being assessed with Life Satisfaction Questionnaire (LSQ; r_s = −0.45; p < 0.01). Found correlation coefficients were slightly stronger after correction for mixed (cortical/subcortical) and purely subcortical lesion location. Conclusions: It can be concluded that infarct volume moderately correlates with long-term motor impairment, functional outcome and quality of life of patients surviving stroke. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 16 gevonden artikelen
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