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| Titel: |
Intraspinal cellular responses after spinal cord transection in rats: neuronal expression of growth-associated protein (GAP-43) |
| Auteur: |
Wiese, Uwe H. Emson, Piers C. |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 2 (2011) nr. 4-6 pagina's 199-204 |
| Jaar: |
2011-05-06 |
| Inhoud: |
The methods of non-radioisotopic in situ hybridization and immunocytochemistry were used to visualize sites of GAP-43 expression after a mid-thoracic spinal cord transection in adult rats. Neurons which expressed moderate to high levels of GAP-43 mRNA and showed strong GAP-43-like immunoreactivity were located immediately above the lesion site as well as at greater distances from the lesion site in the lower cervical and mid-lumbar spinal cord. The results of this study suggest a widespread occurrence of lesion-induced neuroplastic changes and may indicate that the increase in GAP-43 expression can be caused by axotomy, deafferentation and increased compensatory motor activity in the spinal cord of paraplegic rats. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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