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| Titel: |
The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord |
| Auteur: |
M.H. Spilker I.V. Yannas S.K. Kostyk T.V. Norregaard H-P. Hsu M. Spector |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 18 (2001) nr. 1 pagina's 23-38 |
| Jaar: |
2001-11-13 |
| Inhoud: |
Purpose: The purpose of this study was to characterize the effects of implantation of a collagen tube on healing and scar formation following transection of tbc adult rat spinal cord. Methods: The spinal cords of adult rats were completely transected at the mid-thoracic level. At 30 days after injury, the cellular and extra-cellular components of repair tissue present within tubulated and non-tubulated (control) wounds were compared using qualitative and quantitative histological techniques. Results: The presence of the tube reduced fibrocollagenous scar invasion into the gap, promoted astrocyte migration, and oriented axonal and connective tissue components of the repair tissue. Tube implants supported the regeneration of a substantial number of myelinated axons. A notable finding was the identification of cells containing a contractile actin isoform in the healing spinal cord. Conclusions: The tubulation model allows for the study of spinal cord wound healing and axon elongation in a controlled experimental environment within the tube lumen. Using this model, it will be possible to study manipulation of the healing response by the introduction of exogenous agents within the tube |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 4 gevonden artikelen
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