Digitale Bibliotheek
Sluiten Bladeren door artikelen uit een tijdschrift
 
<< vorige    volgende >>
     Tijdschrift beschrijving
       Alle jaargangen van het bijbehorende tijdschrift
         Alle afleveringen van het bijbehorende jaargang
           Alle artikelen van de bijbehorende aflevering
                                       Details van artikel 4 van 7 gevonden artikelen
 
 
  Independent component analysis algorithms for microarray data analysis
 
 
Titel: Independent component analysis algorithms for microarray data analysis
Auteur: Malutan, Raul
Gómez Vilda, Pedro
Borda, Monica
Verschenen in: Intelligent data analysis
Paginering: Jaargang 14 (2010) nr. 2 pagina's 193-206
Jaar: 2010-03-15
Inhoud: Oligonucleotide Microarrays have become powerful tools in Genetic Research, as they serve as parallel scanning mechanisms to detect the presence of genes using test probes composed of controlled segments of gene code built by masking techniques. The detection of each gene depends on the multichannel differential expression of perfectly matched segments against mismatched ones. This methodology, devised to robustify the detection process posses some interesting problems under the point of view of Genomic Signal Processing, as test probes express themselves in rather different patterns, not showing proportional expression levels for most of the segment pairs, as it would be expected. These cases may be influenced by unexpected hybridization dynamics, and are worth of being studied with a double objective: gain insight into hybridization dynamics in microarrays, and to improve microarray production and processing as well. Two methods are proposed in this paper: modelling the dynamics of expression dynamics and isolating gene expressions showing unexpected behaviour to proceed in their further classification and study.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details van artikel 4 van 7 gevonden artikelen
 
<< vorige    volgende >>
 
 Koninklijke Bibliotheek - Nationale Bibliotheek van Nederland