Classic instrument design does not always match the physical capacity of the musician, as instruments are often chosen because of the pleasing sound and not the ease of play. Devices that are commercially available to create a more ergonomic structure may not address the specific needs of a musician with a chronic condition. Through basic splinting of the musician with an injury, these physical stressors can be reduced, allowing the continuation of musical practice and performance. Appropriate design modification requires a solid understanding of upper extremity anatomy, splint design technique, and the biomechanic principles of playing the instrument. Through knowledge of music theory and appreciation, one may modify the instrument while protecting tonal flexibility, resonance, mechanical freedom, and sound quality. Two case studies present a range of splint design, from small to large, static to dynamic, and for congenital or chronic conditions.