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| Titel: |
A Novel Skeletal Drug Delivery System Using Self-Setting Bioactive Glass Bone Cement IV: Cephalexin Release From Cement Containing Polymer-Coated Bulk Powder |
| Auteur: |
Otsuka, Makoto Matsuda, Yoshihisa Kokubo, Tadashi Yoshihara, Satoru Nakamura, Takashi Yamamuro, Takao |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 3 (2012) nr. 4 pagina's 229-236 |
| Jaar: |
2012-02-08 |
| Inhoud: |
A novel device consisting of Eudragit-coated cephalexin as a model drug and a self-setting bioactive cement based upon CaO-SiO2-P2O5 glass was investigated. The glass cement hardened within 5 min of mixing with a phosphate buffer. After setting, in vitro drug release from homogeneous or heterogeneous drug-loaded cement pellets in a simulated body fluid (SBF) at pH 7.25 and 37deg;C continued for over 2 weeks. The hardened cement gradually formed low-crystallinity hydroxyapatite and decreased in volume by about 5% during drug release in SBF. Consequently, 30% of the loaded drug was initially released from the homogeneous cement system, and thereafter it was released more slowly. Since the heterogeneous system consisting of the cement and a 50% polymer coated, drug-loaded pellet avoided this drug's burst, the drug was released over a longer period than that in the homogeneous system. The heterogeneous system released the polymer-coated drug very slowly, because it completely avoided the initial burst, and sustained the release over a long period. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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