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  Electrospun nanofibrous 3D scaffold for bone tissue engineering
 
 
Titel: Electrospun nanofibrous 3D scaffold for bone tissue engineering
Auteur: Eap, Sandy
Ferrand, Alice
Mendoza Palomares, Carlos
Hébraud, Anne
Stoltz, Jean-François
Mainard, Didier
Schlatter, Guy
Benkirane-Jessel, Nadia
Verschenen in: Bio-medical materials and engineering
Paginering: Jaargang 22 (2012) nr. 1-3 pagina's 137-141
Jaar: 2012-07-05
Inhoud: Tissue engineering aims at developing functional substitutes for damaged tissues by mimicking natural tissues. In particular, tissue engineering for bone regeneration enables healing of some bone diseases. Thus, several methods have been developed in order to produce implantable biomaterial structures that imitate the constitution of bone. Electrospinning is one of these methods. This technique produces nonwoven scaffolds made of nanofibers which size and organization match those of the extracellular matrix. Until now, seldom electrospun scaffolds were produced with thickness exceeding one millimeter. This article introduces a new kind of electrospun membrane called 3D scaffold of thickness easily exceeding one centimeter. The manufacturing involves a solution of poly(ε-caprolactone) in DMF/DCM system. The aim is to establish parameters for electrospinning in order to characterize these 3D scaffolds and, establish whether such scaffolds are potentially interesting for bone regeneration.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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