|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 20 van 24 gevonden artikelen
| Titel: |
The correlation between hepatitis B virus infection and IL-27 |
| Auteur: |
Wang, Hong-Liang Zhang, Hai-Yan Zhai, Zhong-Liang Zhou, Xin |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 22 (2012) nr. 1-3 pagina's 187-193 |
| Jaar: |
2012-07-05 |
| Inhoud: |
Objective: To investigate the correlation between HBV infection and interleukin 27 (IL-27). Methods: Serum IL-27 levels in patients with HBV infection and in healthy individuals were measured by ELISA, regulation of IL-27 by HBV in vitro were analyzed by RT-PCR and ELISA. Results: IL-27 was significantly elevated in patients as compared to healthy individuals (P<0.001). IL-27 was also detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with acute hepatitis B or chronic hepatitis B (P<0.05). We also found that IL-27 expression was influenced by HBV e antigen. In addition, our in vitro studies demonstrated that mRNA and protein expression were all stimulated in cells transfected with infectious HBV clone. Conclusions: IL-27 would be a novel cytokine for clinical management of HBV-infected patients, which may establish novel HBV therapeutic approaches. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 20 van 24 gevonden artikelen
| << vorige | volgende >> |