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Details for article 4 of 9 found articles
| Title: |
Injectable CMC/PEI gel as an in vivo scaffold for demineralized bone matrix |
| Author: |
Kim, Kyung Sook Kang, Yun Mi Lee, Ju Young Kim, E. Sle Kim, Chun Ho Min, Byoung Hyun Lee, Hai Bang Kim, Jae Ho Kim, Moon Suk |
| Appeared in: |
Bio-medical materials and engineering |
| Paging: | Volume 19 (2010) nr. 6 pages 381-390 |
| Year: |
2010-03-15 |
| Contents: |
A number of materials have been considered as sources of grafts to repair bone defects. Here, we examined the possibility of creating in situ-forming gels from sodium carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM). The interaction between anionic CMC and cationic PEI was examined by evaluating phase transition behavior and viscosity of CMC solutions containing 0–30 wt% PEI. CMC solutions containing 10 wt% PEI exhibited a sol-to-gel phase transition at temperatures greater than 35°C. The phase transition is caused by electrostatic crosslinking of the CMC/PEI solution to form a gel with a three-dimensional network structure. In situ-formed gel implants were successfully fabricated in vivo by simple subcutaneous injection of the CMC/PEI (90/10) solution (with and without DBM) into Fisher rats. The resulting in situ-formed implant maintained its shape for 28 days in vitro and in vivo. Our results show that in situ-forming CMC/PEI gels can serve as a DBM carrier that can be delivered with a minimally invasive procedure. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 9 found articles
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