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| Titel: |
Collagen-based biomaterials and cartilage engineering. Application to osteochondral defects |
| Auteur: |
Chajra, H. Rousseau, C.F. Cortial, D. Ronzière, M.C. Herbage, D. Mallein-Gerin, F. Freyria, A.M. |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 18 (2008) nr. supplement-1 pagina's 33-45 |
| Jaar: |
2008-03-10 |
| Inhoud: |
Articular cartilage has a limited capacity for self-repair after trauma. Besides the conventional surgical techniques for repairing such defects, treatments involve implantation of autologous cells in suspension or within a variety of cell carrying scaffolds such as hyaluronic acid, alginate, agarose/alginate, fibrin or collagen. For the repair of full-thickness osteochondral defects, tissue engineers started to design single- or bi-phased scaffold constructs often containing hydroxyapatite-collagen composites, usually used as a bone substitute. The purpose of this study was to compare the behavior of bovine chondrocytes cultured in collagen-based scaffolds containing or not hydroxyapatite and cross-linked following two different methods. Calf chondrocytes seeded within Hemotèse® and Collapat® II sponges (SYMATESE biomaterials), chemically cross-linked with glutaraldehyde or EDC/NHS, were maintained up to one month in culture. The cells exhibited a similar behavior in the four scaffolds regarding proliferation level, deposition of glycosaminoglycans in the scaffolds and gene expression of types I, II and X collagens, aggrecan, MMP-1, -13 and the integrin subunits α10 and α11. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 13 gevonden artikelen
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