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| Titel: |
Degradation behaviour in vitro for poly(D,L-lactide-co-glycolide) as drug carrier |
| Auteur: |
Jin Soo Lee Gang Soo Chae Moon Suk Kim Sun Hang Cho Hai Bang Lee Gilson Khang |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 14 (2004) nr. 2 pagina's 185-192 |
| Jaar: |
2004-05-17 |
| Inhoud: |
Biodegradable polymers have been extensively investigated because of regulating drug release rate easily, obviating the need to remove the device, and good biocompatibility. Among the biodegradable polymers currently under investigation, poly(D,L-lactide-co-glycolide) (PLGA) copolymers are the most widely studied because of their long history of safe clinical use as drug carrier. 50 :50 PLGA was used as a model degradable polymer in this study to investigate the degradation behaviour on drug release from bulk degradable polymers in vitro. 5-fluorouracil (5-FU) was used as a model drug. Molecular weight change, residual mass, water uptake, morphological change of PLGA wafers, and pH of release test medium were characterized to investigate the effect of polymer degradation on drug release. The release rate of 5-FU increased with the increase of 5-FU loading amount and the release profiles of 5-FU irrespective of 5-FU loading amount followed near first order release kinetics. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 10 gevonden artikelen
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