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| Titel: |
TEM observation of seven retrieved total knee joints made of Co-Cr-Mo and Ti-Al-V alloys |
| Auteur: |
Shizuko Ichinose Takeshi Muneta Hideki Aoki Motoki Tagami |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 13 (2003) nr. 2 pagina's 125-134 |
| Jaar: |
2003-06-03 |
| Inhoud: |
We demonstrate that a myriad of fine particles produced by the abrasion of both cobalt-chromium-molybdenum (Co-Cr-Mo) and titanium-aluminum-vanadium (Ti-Al-V) alloys accumulate in the synovial cells next to surgical implants made from these alloys. The metallic particles were of various sizes, and were observed within the lysosomes. Energy dispersive X-ray spectroscopy studies revealed that the fine spherical particles consisted solely of Cr, and that other larger particles were composed of the Co-Cr-Mo alloy. We measured the size of the metallic particles using the public domain NIH image program, and found that most of the fine spherical particles were 10-15 nm in diameter (n=1000). Eighty percent of the large particles were 30-35 nm in length and 20-25 nm in width (n=300). In addition, EDS examination clarified that all of the fine particles of the Ti-Al-V alloy were composed of that alloy. For this alloy, when discounting the larger particles, the fine metal deposits were 20-25 nm in length and 10-15 nm in width (n=1000). From these findings, we conclude that the Co-Cr-Mo alloy is easily corroded and that Co is released from the cells. In contrast, the Ti-Al-V alloy is very stable and does not corrode, although the Ti-Al-V alloy does produce particles that are smaller than those produced by the Co-Cr-Mo alloy. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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