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| Titel: |
Effect of oligofucose derivatives on acetic acid-induced gastric ulcer in rats |
| Auteur: |
Hideyuki Shibata Masato Nagaoka Itsuko-Kimura Takagi Shusuke Hashimoto Ritsuo Aiyama Teruo Yokokura |
| Verschenen in: |
Bio-medical materials and engineering |
| Paginering: | Jaargang 11 (2001) nr. 1 pagina's 55-61 |
| Jaar: |
2001-04-01 |
| Inhoud: |
This study attempted to enhance the anti-ulcer activity of fucoidan from Cladosiphon okamuranus TOKIDA by chemical modification with a hydrophobic group. The suitable number of fucose residues in the effective compound was also clarified to obtain a compound of constant quality. Degraded fucoidans were coupled with several hydrophobic groups via Schiff bases, and their anti-ulcer activities were determined by acetic acid-induced ulcer models in rats. Size-fractionated oligofucose was also modified and assayed for anti-ulcer activity. Among the modified oligofucoses, only the oligofucose-dodecylaniline combination (OFDA) significantly promoted ulcer healing. The effective dose was 0.2 mg/kg/d. The most suitable number of fucose residues in the compound for the anti-ulcer activity was determined to be around 12. We succeeded in enhancing the anti-ulcer activity of Cladosiphon fucoidan by modification with dodecylaniline. The activity of this compound was comparable or greater than that of typical anti-ulcer agents. By determination of the optimal OF chain length for the anti-ulcer activity of OFDA, it became possible to obtain OFDA of constant quality. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 6 gevonden artikelen
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