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Details for article 13 of 33 found articles
| Title: |
Honeycomb form β-tricalcium phosphate induces osteogenesis by geometrical property with BMSC |
| Author: |
Yagami, Kimitoshi Shirota, Tatsuo Shintani, Satoru Mayahara, Mitsuori Nishizawa, Mikio Yanagisawa, Shigeru Sammons, Rachel Kuboki, Yoshinori |
| Appeared in: |
Bio-medical materials and engineering |
| Paging: | Volume 21 (2012) nr. 5-6 pages 291-306 |
| Year: |
2012-05-04 |
| Contents: |
To establish an effective method for bone augmentation, we introduced a new honeycomb-like β-tricalcium phosphate (H-β-TCP) with BMP-2 as a scaffold, whose unique geometrical properties induce osteoblastic differentiation of autologous bone marrow mesenchymal stem cells (BMSCs). A total of six beagle dogs from 6 to 7 years old were used for this study. BMSCs were cultured with autologous serum and BMP-2 on H-β-TCP. Differentiation to osteoblasts was demonstrated in vitro and exo vivo. Scanning electron microscopy revealed formation and calcification of a matrix-like structure within the H-β-TCP tunnels in BMSC culture. Moreover, treatment of BMP-2 promoted osteoblastic differentiation of BMSCs in H-β-TCP in a diffusion chamber. These results indicated that H-β-TCP may be a useful tool for construction of functional artificial bone. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 13 of 33 found articles
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