Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
Titel:
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
Auteur:
Jurica, Elizabeth A. Wu, Ximao Williams, Kristin N. Haque, Lauren E. Rampulla, Richard A. Mathur, Arvind Zhou, Min Cao, Gary Cai, Hong Wang, Tao Liu, Heng Xu, Carrie Kunselman, Lori K. Antrilli, Thomas M. Hicks, Michael B. Sun, Qin Dierks, Elizabeth A. Apedo, Atsu Moore, Douglas B. Foster, Kimberly A. Cvijic, Mary Ellen Panemangalore, Reshma Khandelwal, Purnima Wilkes, Jason J. Zinker, Bradley A. Robertson, Donald G. Janovitz, Evan B. Galella, Michael Li, Yi-Xin Li, Julia Ramar, Thangeswaran Jalagam, Prasada Rao Jayaram, Ramya Whaley, Jean M. Barrish, Joel C. Robl, Jeffrey A. Ewing, William R. Ellsworth, Bruce A.