Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
Titel:
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
Auteur:
Patel, Meena V. Peltier, Hillary M. Matulenko, Mark A. Koenig, John R. C. Scanio, Marc J. Gum, Rebecca J. El-Kouhen, Odile F. Fricano, Meagan M. Lundgaard, Greta L. Neelands, Torben Zhang, Xu-Feng Zhan, Cenchen Pai, Madhavi Ghoreishi-Haack, Nayereh Hudzik, Thomas Gintant, Gary Martin, Ruth McGaraughty, Steve Xu, Jun Bow, Daniel Kalvass, John C. Kym, Philip R. DeGoey, David A. Kort, Michael E.