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Details van artikel 5 van 14 gevonden artikelen
| Titel: |
Cytogenetic evolution of human ovarian cell lines associated with chemoresistance and loss of tumorigenicity |
| Auteur: |
Stéphanie Struski Martine Doco-Fenzy Michael Koehler Ilse Chudoba Francis Levy Linda Masson Nicole Michel Evelyne Ulrich Nadine Gruson Jean Bénard Gérard Potron Pascale Cornillet-Lefebvre |
| Verschenen in: |
Analytical cellular pathology |
| Paginering: | Jaargang 25 (2003) nr. 3 pagina's 115-122 |
| Jaar: |
2003-11-11 |
| Inhoud: |
In order to identify genomic changes associated with a resistant phenotype acquisition, we used comparative genomic hybridization (CGH) to compare a human ovarian cell line, Igrov1, and four derived subcell lines, resistant to vincristine and presenting a reversion of malignant properties. Multicolor FISH (Multiplex-FISH and Spectral Karyotype) and conventional FISH are also used to elucidate the karyotype of parental cell line. The drug-resistant subcell lines displayed many chromosomal abnormalities suggesting the implication of different pathways leading to a multidrug resistance phenotype. However, these cell lines shared two common rearrangements: an unbalanced translocation der(8)t(8;13)(p22;q?) and a deletion of the 11p. These chromosomal imbalances could reflected the acquisition of the chemoresistance (der(8)) or the loss of tumorigenicity properties (del(11p)). Colour figure can be viewed on http://www.esacp.org/acp/2003/25-3/struski.htm. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 14 gevonden artikelen
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