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Details for article 5 of 12 found articles
| Title: |
High resolution comparative genomic hybridization detects 7-8 megabasepair deletion in PCR amplified DNA |
| Author: |
Jacob Larsen Anne Marie Ottesen Maria Kirchhoff Claes Lundsteen Jørgen K. Larsen |
| Appeared in: |
Analytical cellular pathology |
| Paging: | Volume 23 (2002) nr. 2 pages 61-64 |
| Year: |
2002-05-24 |
| Contents: |
We investigated if any change in spatial resolution of comparative genomic hybridization analysis could be detected when using DNA amplified by degenerate oligonucleotide primed PCR (DOP-PCR) as opposed to the use of unamplified DNA. Five DNA samples from B-cell leukemias with small 11q deletions were amplified by DOP-PCR and analysed by means of high resolution comparative genomic hybridization (HR-CGH) for the evaluation of aberration size detection limit. By means of HR-CGH, we found the detection limit of DOP-PCR CGH for deletions to be between 3 Mbp and 7-8 Mbp. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 12 found articles
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