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                                       Details van artikel 3 van 9 gevonden artikelen
 
 
  Intratumoral variations in DNA ploidy and s-phase fraction in human breast cancer
 
 
Titel: Intratumoral variations in DNA ploidy and s-phase fraction in human breast cancer
Auteur: Conny Arnerlöv
Stefan O. Emdin
Stefan Cajander
Nils-Olof Bengtsson
Björn Tavelin
Göran Roos
Verschenen in: Analytical cellular pathology
Paginering: Jaargang 23 (2002) nr. 1 pagina's 21-28
Jaar: 2002-03-25
Inhoud: To study intratumoral DNA ploidy heterogeneity and S-phase fraction (SPF) variability, we prospectively collected five different samples from 48 breast carcinomas and each sample was analysed separately by flow cytometry. Aneuploidy rate was 89.6% after analysis of four or five samples. DNA ploidy heterogeneity, i.e., different samples classified as either DNA euploid or DNA aneuploid in the same tumor was seen in 17%, and DNA index heterogeneity, i.e., tumor populations with different DNA indices (DIs) seen in different samples was 44%. A statistical model defining SPF heterogeneity is proposed. SPF heterogeneity as defined by us was 71%, and as expected the SPF heterogeneity rate increased significantly with increasing number of analysed samples. Four or more samples are needed to detect the most deviant (highest) SPF values. An unrecognized intratumor heterogeneity of DNA ploidy and SPF may partly explain the conflicting results reported in the literature on the above prognostic indicators.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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