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  AgNOR count in resting cells (resting NOR) is a new prognostic marker in invasive bladder tumor
 
 
Titel: AgNOR count in resting cells (resting NOR) is a new prognostic marker in invasive bladder tumor
Auteur: Mitsuro Tomobe
Toru Shimazui
Katsunori Uchida
Hideyuki Akaza
Verschenen in: Analytical cellular pathology
Paginering: Jaargang 22 (2001) nr. 4 pagina's 193-199
Jaar: 2001-09-19
Inhoud: Purpose: We have previously demonstrated that the AgNOR count in proliferating cells is a predictor of tumor recurrence in superficial bladder tumor (J. Urol. 162 (1999), 63–68). In the present study, we evaluate the type of AgNOR associated with cell cycles as a prognostic factor in invasive bladder tumor using a double staining technique employing both AgNOR and MIB-1 labelling. Materials and methods: Forty-four paraffin sections of invasive bladder tumors were stained simultaneously with AgNOR and MIB-1. The number of AgNORs in proliferating (MIB-1 positive) or resting (MIB-1 negative) cells were counted from a total of 100 nuclei. Correlations between MIB-1 associated AgNOR count and clinicopathological parameters were statistically analyzed. Results: The AgNOR count in proliferating cells (proliferating NOR) was significantly higher than that in resting cells (resting NOR) (p<0.01). The resting NOR in tumors with distant metastases was significantly higher than that in tumors without metastases (p<0.05). Patients with a low resting NOR tumor had a better prognosis than those with a high resting NOR tumor, whereas the proliferating NOR was not associated with survival. Survival analysis revealed that the resting NOR was the most powerful prognostic marker in patients with invasive bladder tumor (p<0.05). Conclusions: Resting NOR had a predictive value in the prognosis of patients with invasive bladder tumor.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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