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Details van artikel 5 van 14 gevonden artikelen
| Titel: |
Different proliferation patterns in breast cancer: AgNOR measurements in ER-negative and ER-positive tumor cells |
| Auteur: |
Lukas Günther Peter Hufnagl Klaus-Jürgen Winzer Hans Guski |
| Verschenen in: |
Analytical cellular pathology |
| Paginering: | Jaargang 20 (2001) nr. 4 pagina's 155-162 |
| Jaar: |
2001-04-01 |
| Inhoud: |
The relation between estrogen receptors (ER) and argyrophilic nucleolar organizer regions (AgNORs) in situ within human breast cancer cells was analyzed. For AgNOR measurements in 49 invasive breast carcinomas, a new reproducible staining method for dual demonstration of ER and AgNORs was applied. Quantitative AgNOR variables were determined in ER-positive and ER-negative tumor cells by digital image analysis. The relationships between AgNOR parameters of ER-positive and ER-negative cells and other prognostic factors of breast cancer [BloomRichardson-Grading and growth fraction (Ki-67 index)] were investigated. A higher AgNOR content in ER-negative cells and a special clustering phenomenon in ER-positive tumor cells were found. Correlation with other criteria of malignant potential could be exclusively demonstrated for ER-negative cells. ER-negative cells of breast cancer can be characterized as the more malignant and possibly prognosis-dictating cell fraction. Thus, ER-negative cells probably contribute more to the progression of the tumor disease and furthermore to the prognosis than ER-positive cells. We recommend measurement AgNORs exclusively in ER-negative cells of breast cancer. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 14 gevonden artikelen
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