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| Titel: |
Flow cytometric DNA index and karyotype in childhood lymphoblastic leukemia |
| Auteur: |
Erik Forestier Gösta Holmgren Göran Roos |
| Verschenen in: |
Analytical cellular pathology |
| Paginering: | Jaargang 17 (2001) nr. 3 pagina's 145-156 |
| Jaar: |
2001-04-01 |
| Inhoud: |
Flow cytometric DNA-index (DI^{\rm FCM}) and karyotype were analysed in 82 consecutive children with acute lymphoblastic leukemia (ALL) during a 10 year period. A statistically significant correlation existed between modal chromosome number and DI^{\rm FCM} (p=0.009). DI^{\rm FCM} could reliably identify leukemias with >51 chromosomes, whereas only three out of 12 cases with modal chromosome numbers between 4751 were classified as aneuploid by DI^{\rm FCM}. In the pseudodiploid group only one out of 20 leukemias had a DI^{\rm FCM}>1.0. Five leukemias with a diploid karyotype showed an aneuploid DI^{\rm FCM} and in three patients the flow cytometric measurement revealed biclonality undetected by karyotyping. During treatment aneuploid clones could be detected by DI^{\rm FCM} in a substantial number of cases where the cytogenetic analysis was normal, and the opposite was also demonstrated in one case. DI^{\rm FCM} gave prognostic information, showing that cases with a DI >1.12 (corresponding to 51 chromosomes) had a superior outcome with treatment protocols today in use. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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