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  Flow cytometric DNA index and karyotype in childhood lymphoblastic leukemia
 
 
Titel: Flow cytometric DNA index and karyotype in childhood lymphoblastic leukemia
Auteur: Erik Forestier
Gösta Holmgren
Göran Roos
Verschenen in: Analytical cellular pathology
Paginering: Jaargang 17 (2001) nr. 3 pagina's 145-156
Jaar: 2001-04-01
Inhoud: Flow cytometric DNA-index (DI^{\rm FCM}) and karyotype were analysed in 82 consecutive children with acute lymphoblastic leukemia (ALL) during a 10 year period. A statistically significant correlation existed between modal chromosome number and DI^{\rm FCM} (p=0.009). DI^{\rm FCM} could reliably identify leukemias with >51 chromosomes, whereas only three out of 12 cases with modal chromosome numbers between 47–51 were classified as aneuploid by DI^{\rm FCM}. In the pseudodiploid group only one out of 20 leukemias had a DI^{\rm FCM}>1.0. Five leukemias with a diploid karyotype showed an aneuploid DI^{\rm FCM} and in three patients the flow cytometric measurement revealed biclonality undetected by karyotyping. During treatment aneuploid clones could be detected by DI^{\rm FCM} in a substantial number of cases where the cytogenetic analysis was normal, and the opposite was also demonstrated in one case. DI^{\rm FCM} gave prognostic information, showing that cases with a DI >1.12 (corresponding to 51 chromosomes) had a superior outcome with treatment protocols today in use.
Uitgever: IOS Press
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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