PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck
Titel:
PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck
Auteur:
Karin Nylander Elsy-Britt Schildt Mikael Eriksson Göran Roos
Verschenen in:
Analytical cellular pathology
Paginering:
Jaargang 14 (2001) nr. 2 pagina's 101-110
Jaar:
2001-04-01
Inhoud:
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 414 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The tumour site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.