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| Titel: |
The effect of low-dose aspirin treatment on biochemical markers in pregnant hypertensive patients |
| Auteur: |
Bar, J. Rabinerson, D. Padoa, A. Nitzan, Z. Neri, A. Fisch, B. Hod, M. |
| Verschenen in: |
International journal of risk & safety in medicine |
| Paginering: | Jaargang 10 (2013) nr. 4 pagina's 249-254 |
| Jaar: |
2013-03-19 |
| Inhoud: |
We evaluated the known metabolic effects of aspirin in pregnant hypertensive patients. Eighty-seven pregnant women (12th–24th gestational week) were randomly allocated to low-dose aspirin or placebo treatment. Between the 24th–28th gestational week the following tests were performed: oral glucose tolerance test, venous blood pH and base excess, coagulation profile, platelet count, morning (8 a.m.) cortisol, creatinine clearance and serum uric acid. A significantly higher serum uric acid level was detected in the low-dose aspirin group (5.6±2.2 mg/dl) compared with the placebo group (4.7±1.2 mg/dl, p=0.048). No other significant difference was found for any of the other parameters tested. We conclude that low-dose aspirin treatment during the second half of pregnancy in hypertensive patients seems safe in terms of its effect on various maternal metabolic effects. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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