Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism 1 1 Abbreviations used are: JAK, Janus kinase; STAT, signal transducer and activator transcription factor; IL-6, interleukin-6; IFN-γ, interferon γ; ETOH, ethanol; 4-MP, 4-methylpyrazole; DMSA, DNA mobility shift assay; ADH, alcohol dehydrogenase; CYP2E1, cytochrome p450(2E1); EGF, epidermal growth factor; H2O2, hydrogen peroxide.
Titel:
Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism 1 1 Abbreviations used are: JAK, Janus kinase; STAT, signal transducer and activator transcription factor; IL-6, interleukin-6; IFN-γ, interferon γ; ETOH, ethanol; 4-MP, 4-methylpyrazole; DMSA, DNA mobility shift assay; ADH, alcohol dehydrogenase; CYP2E1, cytochrome p450(2E1); EGF, epidermal growth factor; H2O2, hydrogen peroxide.
Auteur:
Chen, Jianping Clemens, Dahn L Cederbaum, Arthur I Gao, Bin