The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1 ☆ Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001). 1 Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethylenimine; RAL, relative adduct labeling; TLC, thin-layer chromatography
Titel:
The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1 ☆ Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001). 1 Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethylenimine; RAL, relative adduct labeling; TLC, thin-layer chromatography
Auteur:
Stiborová, Marie Bieler, Christian A. Wiessler, Manfred Frei, Eva