Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E1 using lactosylated poly(l-glutamic hydrazide) as a carrier 1 1 Abbreviations: PGE1, prostaglandin E1; PLGA-HZ, poly(l-glutamic hydrazide); Lac-NH-PLGA, lactosylated poly(l-glutamic hydrazide); PGE1 conjugate, prostaglandin E1 prodrug using Lac-NH-PLGA as a carrier; DTPA anhydride, diethylenetriamine-N,N,N′,N″,N″-pentaacetic dianhydride; GPT, glutamic pyruvic transaminase; AUC, area under the plasma concentration-time curve; ROS, reactive oxygen species; and EP receptor, receptor for prostaglandins expressed on a plasma membrane.
Titel:
Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E1 using lactosylated poly(l-glutamic hydrazide) as a carrier 1 1 Abbreviations: PGE1, prostaglandin E1; PLGA-HZ, poly(l-glutamic hydrazide); Lac-NH-PLGA, lactosylated poly(l-glutamic hydrazide); PGE1 conjugate, prostaglandin E1 prodrug using Lac-NH-PLGA as a carrier; DTPA anhydride, diethylenetriamine-N,N,N′,N″,N″-pentaacetic dianhydride; GPT, glutamic pyruvic transaminase; AUC, area under the plasma concentration-time curve; ROS, reactive oxygen species; and EP receptor, receptor for prostaglandins expressed on a plasma membrane.
Auteur:
Akamatsu, Ken Yamasaki, Yasuomi Nishikawa, Makiya Takakura, Yoshinobu Hashida, Mitsuru