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Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H 1 1 Abbreviations: RNase H, ribonuclease H; S-oligo, phosphorothioate-modified oligodeoxyribonucleotide; LUAS, anti-luciferase antisense S-oligo; LUS, S-oligo complementary to LUAS; ASM, S-oligo antisense to Leishmania miniexon; SSM, S-oligo complementary to ASM; HIFBS, heat-inactivated fetal bovine serum; TbRH1, Trypanosoma brucei RNase H1 gene; RACE, rapid amplification of cDNA ends; MBSA, maleylated bovine serum albumin; ODN, oligodeoxyribonucleotide; PCR, polymerase chain reaction; and DMPC, dimyristoyl phosphatidylcholine. |
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Titel: |
Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H 1 1 Abbreviations: RNase H, ribonuclease H; S-oligo, phosphorothioate-modified oligodeoxyribonucleotide; LUAS, anti-luciferase antisense S-oligo; LUS, S-oligo complementary to LUAS; ASM, S-oligo antisense to Leishmania miniexon; SSM, S-oligo complementary to ASM; HIFBS, heat-inactivated fetal bovine serum; TbRH1, Trypanosoma brucei RNase H1 gene; RACE, rapid amplification of cDNA ends; MBSA, maleylated bovine serum albumin; ODN, oligodeoxyribonucleotide; PCR, polymerase chain reaction; and DMPC, dimyristoyl phosphatidylcholine. |
Auteur: |
Mishra, Manjari Bennett, Jabbar R. Chaudhuri, Gautam |
Verschenen in: |
Biochemical pharmacology |
Paginering: |
Jaargang 61 (2001) nr. 4 pagina's 10 p. |
Jaar: |
2001 |
Inhoud: |
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Uitgever: |
Elsevier Science Inc. |
Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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