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Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture 1 1 Abbreviations: ACAT, acyl-coenzyme A: cholesterol O-acyltransferase; F 12511, (S)-2′,3′,5′-trimethyl-4′-hydroxy-α-dodecylthio-phenylacetanilide; DMEM, Dulbecco’s modified Eagle medium; FBS, fetal bovine serum; LDL, low-density lipoprotein; HDL, high-density lipoprotein; SR-BI, scavenger receptor class B, type I; P450scc, cytochrome P450 cholesterol side-chain cleavage; P450c17, cytochrome P450 17 α-hydroxylase; P450c21, cytochrome P450 21-hydroxylase; PMA, phorbol 12-myristate 13-acetate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; cAMP, adenosine 3′5′-cyclic monophosphate; ITS, insulin-transferrin-linoleic acid; and MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. |
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Titel: |
Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture 1 1 Abbreviations: ACAT, acyl-coenzyme A: cholesterol O-acyltransferase; F 12511, (S)-2′,3′,5′-trimethyl-4′-hydroxy-α-dodecylthio-phenylacetanilide; DMEM, Dulbecco’s modified Eagle medium; FBS, fetal bovine serum; LDL, low-density lipoprotein; HDL, high-density lipoprotein; SR-BI, scavenger receptor class B, type I; P450scc, cytochrome P450 cholesterol side-chain cleavage; P450c17, cytochrome P450 17 α-hydroxylase; P450c21, cytochrome P450 21-hydroxylase; PMA, phorbol 12-myristate 13-acetate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; cAMP, adenosine 3′5′-cyclic monophosphate; ITS, insulin-transferrin-linoleic acid; and MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. |
Auteur: |
Junquero, Didier Pilon, Antoine Carilla-Durand, Elizabeth Patoiseau, Jean-François Tarayre, Jean-Pierre Torpier, Gérard Staels, Bart Fruchart, Jean-Charles Colpaert, Françis C. Clavey, Véronique Delhon, André |
Verschenen in: |
Biochemical pharmacology |
Paginering: |
Jaargang 61 (2001) nr. 4 pagina's 12 p. |
Jaar: |
2001 |
Inhoud: |
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Uitgever: |
Elsevier Science Inc. |
Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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