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Tight binding of the angiotensin AT1 receptor antagonist [3H]candesartan is independent of receptor internalization 1 1 Abbreviations: candesartan, 2-ethoxy-1-[(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-benzimidazoline-7-carboxylic acid; CHO-K1, Chinese hamster Ovary cells; CHO-hAT1 cells, CHO-K1 cells expressing human AT1 receptors; CHO-rAT1A-WT, CHO-K1 cells expressing wild type rat AT1A receptors; CHO-TL314-rAT1A, CHO-K1 cells expressing rat AT1A receptors with a truncated cytoplasmic tail at Leucine 314; HEPES, N-[2-hydroxyethyl]piperazine-N′-[ethanesulfonic acid]; IP, inositol mono-, bis- and trisphosphates. |
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Titel: |
Tight binding of the angiotensin AT1 receptor antagonist [3H]candesartan is independent of receptor internalization 1 1 Abbreviations: candesartan, 2-ethoxy-1-[(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-benzimidazoline-7-carboxylic acid; CHO-K1, Chinese hamster Ovary cells; CHO-hAT1 cells, CHO-K1 cells expressing human AT1 receptors; CHO-rAT1A-WT, CHO-K1 cells expressing wild type rat AT1A receptors; CHO-TL314-rAT1A, CHO-K1 cells expressing rat AT1A receptors with a truncated cytoplasmic tail at Leucine 314; HEPES, N-[2-hydroxyethyl]piperazine-N′-[ethanesulfonic acid]; IP, inositol mono-, bis- and trisphosphates. |
Auteur: |
Fierensa, Frederik L.P. Vanderheyden, Patrick M.L. Roggeman, Chantal De Backer, Jean-Paul Thekkumkara, Thomas J. Vauquelin, Georges |
Verschenen in: |
Biochemical pharmacology |
Paginering: |
Jaargang 61 (2001) nr. 10 pagina's 9 p. |
Jaar: |
2001 |
Inhoud: |
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Uitgever: |
Elsevier Science Inc. |
Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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