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Details van artikel 2 van 8 gevonden artikelen
| Titel: |
A physiological phase separation in airway mucus |
| Auteur: |
Braun, F.N. |
| Verschenen in: |
Biorheology |
| Paginering: | Jaargang 46 (2009) nr. 1 pagina's 57-61 |
| Jaar: |
2009-02-27 |
| Inhoud: |
The pathology of the disease cystic fibrosis is known to be associated very generally with ionic imbalance in the mucosal secretion which lines the respiratory tract, so-called airway surface liquid (ASL). The imbalance is caused by mutation of a transmembrane protein (CFTR) implicated in the control of ion traffic across the airway epithelium. It is feasible that CFTR malfunction undermines a putative phase-separated texture of healthy ASL which is apparent in electron microscopy images. A molecular statistical description of ASL is presented here with the aim of illustrating this hypothesis at the phenomenological level. The model predicts that a volume criterion and a salt criterion must be met in order to achieve the phase-separated texture. These predictions help to rationalise the findings of clinical trials. In conjunction with further experimental investigation, molecular statistical approaches in this spirit have the potential to play a useful role in the drive towards treatment strategies. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 8 gevonden artikelen
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