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Details for article 7 of 9 found articles
| Title: |
The hydraulic conductivity of Matrigel™ |
| Author: |
McCarty, William J. Johnson, Mark |
| Appeared in: |
Biorheology |
| Paging: | Volume 44 (2008) nr. 5-6 pages 303-317 |
| Year: |
2008-04-07 |
| Contents: |
In this study, we measured the specific hydraulic conductivity (K) of Matrigel™ at 1% and 2% concentrations as a function of perfusion pressure (0 to 100 mmHg) and compared the results to predictions from two models: a fiber matrix model that predicted K of the gel based upon its composition, and a biphasic model that predicted changes in K caused by pressure induced compaction of the gels. The extent of gel compaction as a function of perfusion pressure was also assessed, allowing us to estimate the stiffness of the gels. As expected, 2% Matrigel™ had a lower K and a higher stiffness than did 1% Matrigel™. Measured values of K of both 1% and 2% Matrigel™ samples showed good agreement with the predictions of the fiber matrix model. Pressure-induced changes in K were better described by the biphasic model than a model in which uniform compression of the gel was assumed. We conclude that K of multi-component gels, such as Matrigel™can be well characterized by fiber matrix models, and that pressure-induced changes in K of such gels can be well characterized by biphasic models. |
| Publisher: |
IOS Press |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 9 found articles
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