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| Titel: |
Age-related quantitative MRI changes in healthy cartilage: Preliminary results |
| Auteur: |
Goebel, Jean Christophe Watrin-Pinzano, Astrid Bettembourg-Brault, Isabelle Odille, Freddy Felblinger, Jacques Chary-Valckenaere, Isabelle Netter, Patrick Blum, Alain Gillet, Pierre Loeuille, Damien |
| Verschenen in: |
Biorheology |
| Paginering: | Jaargang 43 (2006) nr. 3-4 pagina's 547-551 |
| Jaar: |
2006-09-07 |
| Inhoud: |
Objectives: As the early form of OA is characterized by elevated water content in the cartilage tissue, the purpose of this study was to verify in vivo if age-related changes in patellar cartilage in healthy volunteers can be detected using quantitative MRI with T2 mapping and volume measurement MRI methods. Design: Thirty healthy volunteers of various classes of age (18 to 65 years old) were enrolled in this study. MR images of the patellar cartilage were acquired at 1.5T. Patellar cartilage volume and T2 maps were determined. Results: Despite non-significance, there was a trend in reducing cartilage volume with ageing (r: −0.25). In contrast global T2 slightly increased with ageing (r: 0.46). BMI (r: 0.51) and bone volume (r: 0.69) are well correlated to cartilage volume. Conclusion. Age-related physiologic changes in the water content of patellar cartilage can be detected using MRI. The proposed T2-mapping method, coupled with other non-invasive MR cartilage imaging techniques, could aid in the early diagnosis of OA. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 43 gevonden artikelen
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