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                                       Details for article 52 of 57 found articles
 
 
  The effect of cyclical compressive loading on gene expression in articular cartilage
 
 
Title: The effect of cyclical compressive loading on gene expression in articular cartilage
Author: Blain, Emma J.
Mason, Deborah J.
Duance, Victor C.
Appeared in: Biorheology
Paging: Volume 40 (2002) nr. 1-3 pages 111-117
Year: 2002-10-28
Contents: Osteoarthritis (OA) develops as a consequence of articular cartilage degeneration possibly initiated by excessive or abnormal loading of the joint, and potentially mediated through a proteinase/proteinase inhibitor imbalance. We have shown previously that physiological loads (0.5 MPa, 1 Hz, 3 hour) elicit increased expression and activation of the matrix metalloproteinases (MMPs) in articular cartilage explants in vitro. The objective of this study was to identify mechanically-regulated genes involved in the observed induction of MMP expression and enhanced activation. Differential RNA Display (DRD) was used to identify mechanically-regulated genes by comparing DRD products derived from loaded and unloaded cartilage. One gene up-regulated in cartilage after 10, 30 and 60 minute loading revealed 83% homology with Mus musculus thymosin β4 which is known to induce MMP gene expression. The identification of mechanically regulated genes will greatly enhance our understanding of matrix turnover providing an exciting future in elucidating the role of mechanically-regulated genes in the development of OA.
Publisher: IOS Press
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 52 of 57 found articles
 
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