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Details van artikel 18 van 57 gevonden artikelen
| Titel: |
Development of a technique to determine strains in tendons using the cell nuclei |
| Auteur: |
H.R.C. Screen D.A. Lee D.L. Bader J.C. Shelton |
| Verschenen in: |
Biorheology |
| Paginering: | Jaargang 40 (2002) nr. 1-3 pagina's 361-368 |
| Jaar: |
2002-10-28 |
| Inhoud: |
Tenocytes detect mechanical stimuli in vivo, and respond through mechanotransduction pathways to initiate matrix remodelling in tendons. Due to the crimped nature of tendon fascicles, the strain field throughout is non-homogeneous. The present study has developed a means to quantify the local strain fields within a fascicle by monitoring the relative movement and deformation of fluorescently labelled tenocyte nuclei. A stage mounted test rig was designed to apply tensile strain to fascicles. Rat tail and bovine extensor tendons were harvested for analysis, and the cell nuclei stained and visualised using an inverted confocal microscope. As the fascicles were subjected to gross strains of up to 5%, the movement of selected tenocyte nuclei were recorded. Results from a series of cell nuclei from both tendon sources revealed that local strains were significantly less than the applied strain. The nuclei length to width ratio, an indicator of cell deformation, also increased with applied strain, most significantly between 2 and 3% applied strain. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 18 van 57 gevonden artikelen
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