| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A Method of Effectively Improved α-Mangostin Bioavailability
|
Zhao, Yan
|
|
2015
|
|
5 |
p. 605-613
|
artikel
|
| 2 |
Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines
|
Singh, Jasbir
|
|
2018
|
|
5 |
p. 483-494
|
artikel
|
| 3 |
Antifibrotic Effects of Carvedilol and Impact of Liver Fibrosis on Carvedilol Pharmacokinetics in a Rat model
|
El-Demerdash, Ebtehal
|
|
2016
|
|
5 |
p. 767-779
|
artikel
|
| 4 |
Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model
|
Rašković, Aleksandar
|
|
2017
|
|
5 |
p. 849-856
|
artikel
|
| 5 |
A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers
|
Perkins, Daniel
|
|
|
|
5 |
p. 575-586
|
artikel
|
| 6 |
A pH/Time/Pectinase-Dependent Oral Colon-Targeted System Containing Isoliquiritigenin: Pharmacokinetics and Colon Targeting Evaluation in Mice
|
Tang, XiaoFei
|
|
|
|
5 |
p. 677-686
|
artikel
|
| 7 |
A Population Pharmacokinetic and Pharmacodynamic Analysis of RP5063 Phase 2 Study Data in Patients with Schizophrenia or Schizoaffective Disorder
|
Cantillon, Marc
|
|
2018
|
|
5 |
p. 573-585
|
artikel
|
| 8 |
Application of Allometric Scaling and Salisbury Rule for the Prediction of Antimalarial Drugs for First-in-Pediatric Dose Selection
|
Mahmood, Iftekhar
|
|
|
|
5 |
p. 587-594
|
artikel
|
| 9 |
A Quantitative Prediction Method for the Human Pharmacokinetics of Fc-Fusion Proteins
|
Yokoyama, Miki
|
|
|
|
5 |
p. 541-552
|
artikel
|
| 10 |
A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications
|
Elewa, Hazem
|
|
2017
|
|
5 |
p. 745-756
|
artikel
|
| 11 |
A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid, Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats
|
Li, Yongjun
|
|
2015
|
|
5 |
p. 595-603
|
artikel
|
| 12 |
Author’s Reply to: “Comment on: Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor Antagonist GR007 in Chinese Healthy Subjects”
|
Xie, Ran
|
|
2019
|
|
5 |
p. 723-724
|
artikel
|
| 13 |
Bioavailability of a Capsaicin Lipid Multi-particulate Formulation in Rats
|
Sahin, Kazim
|
|
|
|
5 |
p. 645-650
|
artikel
|
| 14 |
Bioequivalence and Tolerability of Ambrisentan: A Pharmacokinetic Study in Mexican Healthy Male Subjects
|
Cárdenas, Karen Paola Camarillo
|
|
|
|
5 |
p. 611-618
|
artikel
|
| 15 |
Characterization of 1-Aminobenzotriazole and Ketoconazole as Novel Inhibitors of Monoamine Oxidase (MAO): An In Vitro Investigation
|
Shaik, Abdul Naveed
|
|
2017
|
|
5 |
p. 827-834
|
artikel
|
| 16 |
Chronopharmacokinetics of Erlotinib and Circadian Rhythms of Related Metabolic Enzymes in Lewis Tumor-Bearing Mice
|
Liu, Jiao
|
|
2015
|
|
5 |
p. 627-635
|
artikel
|
| 17 |
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
|
Al-Sulaiti, Fatima Khalifa
|
|
2019
|
|
5 |
p. 639-652
|
artikel
|
| 18 |
Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives
|
Sulochana, Suresh P.
|
|
2016
|
|
5 |
p. 469-503
|
artikel
|
| 19 |
Clinical Pharmacokinetics and Drug–Drug Interactions of Elbasvir/Grazoprevir
|
Kiang, Tony K. L.
|
|
2018
|
|
5 |
p. 509-531
|
artikel
|
| 20 |
Combining Chemical Permeation Enhancers for Synergistic Effects
|
Toit, Trizel du
|
|
2015
|
|
5 |
p. 575-586
|
artikel
|
| 21 |
Comment on: Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor Antagonist GR007 in Healthy Chinese Subjects
|
Srinivas, Nuggehally R.
|
|
2019
|
|
5 |
p. 719-721
|
artikel
|
| 22 |
Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure–Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite
|
Okour, Malek
|
|
2019
|
|
5 |
p. 629-638
|
artikel
|
| 23 |
Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects
|
Weiss, Karl Heinz
|
|
|
|
5 |
p. 665-675
|
artikel
|
| 24 |
Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives
|
Zerdoug, Anna
|
|
|
|
5 |
p. 621-637
|
artikel
|
| 25 |
Correction to: Bioavailability of a Capsaicin Lipid Multi‑particulate Formulation in Rats
|
Sahin, Kazim
|
|
|
|
5 |
p. 651
|
artikel
|
| 26 |
Correction to: Pharmacokinetic and Pharmacodynamic Studies of Elacestrant, A Novel Oral Selective Estrogen Receptor Degrader, in Healthy Post-Menopausal Women
|
Conlan, Maureen G.
|
|
|
|
5 |
p. 691-692
|
artikel
|
| 27 |
Determination of Puquitinib in Human Plasma by HPLC–ESI MS/MS: Application to Pharmacokinetic Study
|
Zhan, Jing
|
|
2018
|
|
5 |
p. 555-564
|
artikel
|
| 28 |
Development and Stability Study of an Omeprazole Suppository for Infants
|
Bestebreurtje, Petra
|
|
|
|
5 |
p. 627-633
|
artikel
|
| 29 |
Differential Inhibition of Equilibrative Nucleoside Transporter 1 (ENT1) Activity by Tyrosine Kinase Inhibitors
|
Jouan, Elodie
|
|
|
|
5 |
p. 625-635
|
artikel
|
| 30 |
Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)
|
Zailani, Nur Nabihah Binte
|
|
|
|
5 |
p. 467-494
|
artikel
|
| 31 |
Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance
|
Hefny, Fatma
|
|
|
|
5 |
p. 607-620
|
artikel
|
| 32 |
Drug–Drug Interactions of a Novel κ-Opioid Receptor Agonist, Nalfurafine Hydrochloride, Involving the P-Glycoprotein
|
Ando, Akihiro
|
|
2015
|
|
5 |
p. 549-558
|
artikel
|
| 33 |
Effect of Gevokizumab on Interleukin-1β-Mediated Cytochrome P450 3A4 and Drug Transporter Repression in Cultured Human Hepatocytes
|
Moreau, Amélie
|
|
2017
|
|
5 |
p. 871-878
|
artikel
|
| 34 |
Effect of Human Cytochrome P450 2D6 Polymorphism on Progesterone Hydroxylation
|
Niwa, Toshiro
|
|
|
|
5 |
p. 741-747
|
artikel
|
| 35 |
Effect of Nonadherence on Levetiracetam Pharmacokinetics and Remedial Dose Recommendations Using Monte Carlo Simulations
|
Methaneethorn, Janthima
|
|
|
|
5 |
p. 667-676
|
artikel
|
| 36 |
Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction
|
Jana, Snehasis
|
|
2017
|
|
5 |
p. 781-791
|
artikel
|
| 37 |
Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects
|
Luedtke, Doreen
|
|
2018
|
|
5 |
p. 533-541
|
artikel
|
| 38 |
Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males
|
Toyama, Kaoru
|
|
|
|
5 |
p. 685-694
|
artikel
|
| 39 |
Efficacy and Therapeutic Drug Monitoring of Continuous Beta-Lactam Infusion for Osteoarticular Infections Caused by Fluoroquinolone-Resistant Pseudomonas aeruginosa: A Prospective Cohort Study
|
Gómez-Junyent, Joan
|
|
|
|
5 |
p. 587-599
|
artikel
|
| 40 |
Erratum to: Effect of Aroma and Magnum Hops Extracts and Paracetamol on Antioxidant Liver Parameters in Mice
|
Jakovljevic, Vida
|
|
2016
|
|
5 |
p. 651
|
artikel
|
| 41 |
Erratum to: Interaction of Alcoholic Extracts of Hops with Pentobarbital and Diazepam in Mice
|
Raskovic, Aleksandar
|
|
2016
|
|
5 |
p. 653
|
artikel
|
| 42 |
Evaluating the Pharmacokinetics of Fentanyl in the Brain Extracellular Fluid, Saliva, Urine, and Plasma of Newborns from Transplacental Exposure from Parturient Mothers Dosed with Epidural Fentanyl Utilizing PBPK Modeling
|
Alsmadi, Mo’tasem M.
|
|
|
|
5 |
p. 567-586
|
artikel
|
| 43 |
Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans
|
Guan, Chi
|
|
|
|
5 |
p. 639-652
|
artikel
|
| 44 |
Evaluation of the Population Pharmacokinetic Properties of Lidocaine and its Metabolites After Long-Term Multiple Applications of a Lidocaine Plaster in Post-Herpetic Neuralgia Patients
|
Bursi, Roberta
|
|
2017
|
|
5 |
p. 801-814
|
artikel
|
| 45 |
External Validation of a Vancomycin Population Pharmacokinetic Model and Developing a New Dosage Regimen in Neonates
|
Lim, Chuan Poh
|
|
|
|
5 |
p. 687-697
|
artikel
|
| 46 |
First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults
|
Shisha, Tamas
|
|
|
|
5 |
p. 553-566
|
artikel
|
| 47 |
Fluctuations in Pharmacokinetics Profiles of Monoclonal Antibodies
|
Grabowski, Tomasz
|
|
2019
|
|
5 |
p. 585-589
|
artikel
|
| 48 |
Formulation and Pharmacokinetic Evaluation of Polymeric Dispersions Containing Valsartan
|
Chella, Naveen
|
|
2015
|
|
5 |
p. 517-526
|
artikel
|
| 49 |
Gender Differences in the Effect of Calcitriol on the Body Disposition and Excretion of Doxorubicin in Mice
|
Durna Corum, Duygu
|
|
|
|
5 |
p. 653-664
|
artikel
|
| 50 |
Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats
|
Ma, Yan-rong
|
|
2015
|
|
5 |
p. 559-565
|
artikel
|
| 51 |
Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels
|
O’Connor, Kristin
|
|
|
|
5 |
p. 677-684
|
artikel
|
| 52 |
Hydroxylation Metabolisms of Crassicauline A in Rats Under Toxic Dose
|
Fan, Xue
|
|
2017
|
|
5 |
p. 857-869
|
artikel
|
| 53 |
Identifying Safety Thresholds for Immunosuppressive Drugs: Applying Insights from Primary Antibody Deficiencies to Mitigate Adverse Events in Secondary Antibody Deficiencies Using Mathematical Modeling of Preclinical and Early Clinical Data
|
Kareva, Irina
|
|
|
|
5 |
p. 601-611
|
artikel
|
| 54 |
Impact of Menopause on Pharmacokinetics of Rosuvastatin Compared with Premenopausal Women
|
Nazir, Shabnam
|
|
2015
|
|
5 |
p. 505-509
|
artikel
|
| 55 |
Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability
|
Mourão, Artemísia L.
|
|
2015
|
|
5 |
p. 511-515
|
artikel
|
| 56 |
Increased Intestinal Absorption of Genistein by Coadministering Verapamil in Rats
|
Xie, Baogang
|
|
2015
|
|
5 |
p. 637-643
|
artikel
|
| 57 |
Influence of Nutritional Status on the Absorption of Polyphyllin I, an Anticancer Candidate from Paris polyphylla in Rats
|
Yu, Feng-Ling
|
|
2018
|
|
5 |
p. 587-597
|
artikel
|
| 58 |
Influene of Pharmaceutical Excipients on the Membrane Transport of a P-glycoprotein Substrate in the Rat Small Intestine
|
Takizawa, Yusuke
|
|
|
|
5 |
p. 645-652
|
artikel
|
| 59 |
Inhibitory Effect of Vonoprazan on the Metabolism of [14C]Prasugrel in Human Liver Microsomes
|
Nishihara, Mitsuhiro
|
|
2019
|
|
5 |
p. 713-717
|
artikel
|
| 60 |
Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes
|
Lou, Dan
|
|
2019
|
|
5 |
p. 611-618
|
artikel
|
| 61 |
In Vitro Evaluation of Absorption Characteristics of Peramivir for Oral Delivery
|
Li, Ying
|
|
2016
|
|
5 |
p. 757-765
|
artikel
|
| 62 |
In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401
|
Zhang, Jiang Wei
|
|
2019
|
|
5 |
p. 669-680
|
artikel
|
| 63 |
In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione
|
Romański, Michał
|
|
2019
|
|
5 |
p. 653-657
|
artikel
|
| 64 |
In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats
|
Romański, Michał
|
|
2018
|
|
5 |
p. 565-571
|
artikel
|
| 65 |
Metabolic Profile of Isocorynoxeine in Rats Obtained by Ultra-High Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
|
Zhao, Lizhu
|
|
2015
|
|
5 |
p. 615-626
|
artikel
|
| 66 |
Microbial Metabolism of Atovaquone and Cytotoxicity of the Produced Phase I Metabolite
|
Oliveira Silva, Eliane de
|
|
2015
|
|
5 |
p. 645-650
|
artikel
|
| 67 |
Minimal Physiologically Based Pharmacokinetic Model of Intravenously and Orally Administered Delta-9-Tetrahydrocannabinol in Healthy Volunteers
|
Wolowich, William R.
|
|
2019
|
|
5 |
p. 691-711
|
artikel
|
| 68 |
mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond
|
Prakash, Satyendra
|
|
|
|
5 |
p. 515-529
|
artikel
|
| 69 |
Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation
|
Attar, Esha S.
|
|
|
|
5 |
p. 495-514
|
artikel
|
| 70 |
Nonclinical Pharmacokinetic Evaluation of Desidustat: a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia
|
Patel, Harilal
|
|
|
|
5 |
p. 725-740
|
artikel
|
| 71 |
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1
|
Shoieb, Sherif M.
|
|
|
|
5 |
p. 613-624
|
artikel
|
| 72 |
Ocular Pharmacokinetics of 25-Hydroxyvitamin D3 After Weekly Supplementation in Rabbits Using Ultra Performance Liquid Chromatography–Tandem Mass Spectrometer
|
Kumar, Archit
|
|
2018
|
|
5 |
p. 607-613
|
artikel
|
| 73 |
On the Molecular Basis Underlying the Metabolism of Tapentadol Through Sulfation
|
Bairam, Ahsan F.
|
|
2017
|
|
5 |
p. 793-800
|
artikel
|
| 74 |
Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children
|
Thigpen, James C.
|
|
2019
|
|
5 |
p. 591-609
|
artikel
|
| 75 |
Pharmacokinetic and Pharmacodynamic Studies of Elacestrant, A Novel Oral Selective Estrogen Receptor Degrader, in Healthy Post-Menopausal Women
|
Conlan, Maureen G.
|
|
|
|
5 |
p. 675-689
|
artikel
|
| 76 |
Pharmacokinetic Comparison of Nine Bioactive Compounds of Guanxinshutong Capsule in Normal and Acute Myocardial Infarction Rats
|
Yang, Yuting
|
|
|
|
5 |
p. 653-665
|
artikel
|
| 77 |
Pharmacokinetic Modeling and Predictive Performance: Practical Considerations for Therapeutic Monoclonal Antibodies
|
Chen, Yang
|
|
|
|
5 |
p. 595-600
|
artikel
|
| 78 |
Pharmacokinetics and Pharmacogenetics of Carbamazepine in Children
|
Djordjevic, Natasa
|
|
2017
|
|
5 |
p. 729-744
|
artikel
|
| 79 |
Pharmacokinetics and Safety of a Diclofenac Sodium 75 mg/1 mL Solution (Akis®/Dicloin®) Administered as a Single Intravenous Bolus Injection in Healthy Men and Women
|
Leuratti, Chiara
|
|
2019
|
|
5 |
p. 681-689
|
artikel
|
| 80 |
Pharmacokinetics and Safety of Dabigatran Etexilate after Single and Multiple Oral Doses in Healthy Chinese Subjects
|
Duan, Jingli
|
|
|
|
5 |
p. 601-609
|
artikel
|
| 81 |
Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects
|
Xu, Mingzhen
|
|
2015
|
|
5 |
p. 541-548
|
artikel
|
| 82 |
Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C3] in Mice and Primates
|
Hardt, Joshua I.
|
|
2018
|
|
5 |
p. 543-554
|
artikel
|
| 83 |
Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2′-methylguanosine-5′-monophosphate, in the monkey and formulation optimization for human exposure
|
Pan-Zhou, Xin-Ru
|
|
2015
|
|
5 |
p. 567-574
|
artikel
|
| 84 |
Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone (BAY 94-8862) in Individuals with Mild or Moderate Hepatic Impairment
|
Heinig, Roland
|
|
2019
|
|
5 |
p. 619-628
|
artikel
|
| 85 |
Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration
|
Matzneller, Peter
|
|
2018
|
|
5 |
p. 599-606
|
artikel
|
| 86 |
Physiologically-Based Pharmacokinetic Models of CYP2D6 Substrate and Inhibitors Nebivolol, Cinacalcet and Mirabegron to Simulate Drug–Drug Interactions
|
Kilford, Peter
|
|
|
|
5 |
p. 699-710
|
artikel
|
| 87 |
Population Pharmacokinetic Analysis of the Oral Absorption Process and Explaining Intra-Subject Variability in Plasma Exposures of Imatinib in Healthy Volunteers
|
Golabchifar, Ali-Akbar
|
|
2015
|
|
5 |
p. 527-539
|
artikel
|
| 88 |
Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults
|
Sridharan, Kannan
|
|
|
|
5 |
p. 531-540
|
artikel
|
| 89 |
Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer
|
Liao, Mingxiang
|
|
|
|
5 |
p. 711-723
|
artikel
|
| 90 |
Population Pharmacokinetics and Pharmacodynamics of Meropenem in Critically Ill Patients: How to Achieve Best Dosage Regimen According to the Clinical Situation
|
O’Jeanson, Amaury
|
|
|
|
5 |
p. 695-705
|
artikel
|
| 91 |
Population Pharmacokinetics of Voriconazole in Chinese Patients with Hematopoietic Stem Cell Transplantation
|
Chen, Chaoyang
|
|
2019
|
|
5 |
p. 659-668
|
artikel
|
| 92 |
Preclinical Pharmacokinetics and in vitro Metabolism of FHND5071, a Novel Selective RET Kinase Inhibitor
|
Han, Yiran
|
|
|
|
5 |
p. 595-614
|
artikel
|
| 93 |
Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice
|
Nigade, Prashant B.
|
|
2017
|
|
5 |
p. 835-847
|
artikel
|
| 94 |
Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department: A Population Pharmacokinetic Analysis
|
De Winter, Sabrina
|
|
|
|
5 |
p. 653-663
|
artikel
|
| 95 |
Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial
|
Bestebreurtje, Petra
|
|
|
|
5 |
p. 635-643
|
artikel
|
| 96 |
Relationship Between Change Rate of Tacrolimus Clearance During Continuous Intravenous Infusion and Recipient Recovery at an Early Stage After Living Donor Liver Transplantation
|
Nakagawa, Junichi
|
|
|
|
5 |
p. 619-626
|
artikel
|
| 97 |
Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects
|
Muehler, Andreas
|
|
|
|
5 |
p. 557-573
|
artikel
|
| 98 |
Serum and Synovial Vancomycin Concentrations in Patients with Prosthetic Joint Infection after Intra-articular Infusion
|
He, Jia-Wei
|
|
|
|
5 |
p. 637-643
|
artikel
|
| 99 |
Systemic Bioavailability and Dose Proportionality of Omega-3 Administered in Free Fatty Acid Form Compared With Ethyl Ester Form: Results of a Phase 1 Study in Healthy Volunteers
|
Offman, Elliot
|
|
2017
|
|
5 |
p. 815-825
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