| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
|
Wang, Pengyu
|
|
|
|
9 |
p. 1396-1408.e8
|
artikel
|
| 2 |
A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation
|
Suzuki, Sachio
|
|
|
|
9 |
p. 1446-1464.e10
|
artikel
|
| 3 |
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
|
Ehrnhoefer, Dagmar E.
|
|
2019
|
|
9 |
p. 1295-1305.e6
|
artikel
|
| 4 |
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection
|
Vijayan, Kamalakannan
|
|
|
|
9 |
p. 1419-1433.e5
|
artikel
|
| 5 |
A MALDI-TOF Approach to Ubiquitin Ligase Activity
|
van Tol, Bianca D.M.
|
|
2018
|
|
9 |
p. 1053-1055
|
artikel
|
| 6 |
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria
|
Tong, Yang
|
|
|
|
9 |
p. 1104-1114.e7
|
artikel
|
| 7 |
Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins
|
Pisa, Rudolf
|
|
2019
|
|
9 |
p. 1263-1273.e5
|
artikel
|
| 8 |
A New Staple: Peptide-Targeted Covalent Inhibitors
|
Leverson, Joel D.
|
|
2016
|
|
9 |
p. 1043-1044
2 p.
|
artikel
|
| 9 |
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals
|
Miller, Simon
|
|
|
|
9 |
p. 1192-1198.e5
|
artikel
|
| 10 |
A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity
|
Kim, Joon T.
|
|
|
|
9 |
p. 1130-1139.e4
|
artikel
|
| 11 |
Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases
|
Kudithipudi, Srikanth
|
|
2016
|
|
9 |
p. 1049-1055
7 p.
|
artikel
|
| 12 |
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
|
Velagapudi, Sai Pradeep
|
|
2018
|
|
9 |
p. 1086-1094.e7
|
artikel
|
| 13 |
A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome
|
Bak, Daniel W.
|
|
2018
|
|
9 |
p. 1157-1167.e4
|
artikel
|
| 14 |
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
|
Birnbaum, Michael D.
|
|
|
|
9 |
p. 1220
|
artikel
|
| 15 |
Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology
|
Kostic, Milka
|
|
2016
|
|
9 |
p. 1039-1040
2 p.
|
artikel
|
| 16 |
Bioorthogonal dissection of the replicase assembly of hepatitis C virus
|
Zhang, Yang
|
|
|
|
9 |
p. 1366-1378.e4
|
artikel
|
| 17 |
Boosting glycolysis to combat fragile bone in type 1 diabetes
|
Jin, Zixue
|
|
|
|
9 |
p. 1002-1003
|
artikel
|
| 18 |
Break Away: FKBP12 sequestration as a target for increasing BMP activity
|
Taubert, Martha C.
|
|
|
|
9 |
p. 1253-1255
|
artikel
|
| 19 |
Bypassing Kinase Signaling in Mammalian Cells
|
Neumann, Heinz
|
|
2018
|
|
9 |
p. 1051-1053
|
artikel
|
| 20 |
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria
|
Emslander, Quirin
|
|
|
|
9 |
p. 1434-1445.e7
|
artikel
|
| 21 |
Challenges and opportunities in targeting metabolism
|
Birsoy, Kivanç
|
|
|
|
9 |
p. 999-1001
|
artikel
|
| 22 |
Chemical Biology as a Driver of Innovation in Cancer Research and Drug Discovery
|
Kostic, Milka
|
|
2017
|
|
9 |
p. 1057-
1 p.
|
artikel
|
| 23 |
Chemical Inhibition of Protein Methyltransferases
|
Schapira, Matthieu
|
|
2016
|
|
9 |
p. 1067-1076
10 p.
|
artikel
|
| 24 |
Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene
|
Wang, Shao-Ru
|
|
2016
|
|
9 |
p. 1113-1122
10 p.
|
artikel
|
| 25 |
Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
|
Brand, Silke
|
|
2018
|
|
9 |
p. 1095-1106.e23
|
artikel
|
| 26 |
Context-dependent regulation of ferroptosis sensitivity
|
Magtanong, Leslie
|
|
|
|
9 |
p. 1409-1418.e6
|
artikel
|
| 27 |
Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage
|
Chirgwin, Michael E.
|
|
|
|
9 |
p. 1365-1367
|
artikel
|
| 28 |
Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption
|
Lawrence, Nicole
|
|
2018
|
|
9 |
p. 1140-1150.e5
|
artikel
|
| 29 |
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
|
Skwarska, Anna
|
|
|
|
9 |
p. 1258-1270.e13
|
artikel
|
| 30 |
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis
|
Zupancic, Jennifer M.
|
|
|
|
9 |
p. 1379-1388.e7
|
artikel
|
| 31 |
Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
|
McAuley, Scott
|
|
2019
|
|
9 |
p. 1274-1282.e4
|
artikel
|
| 32 |
Discovery of compounds that reactivate p53 mutants in vitro and in vivo
|
Durairaj, Geetha
|
|
|
|
9 |
p. 1381-1395.e13
|
artikel
|
| 33 |
Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection
|
Raphemot, Rene
|
|
2019
|
|
9 |
p. 1253-1262.e5
|
artikel
|
| 34 |
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
|
Kang, Seong A.
|
|
2019
|
|
9 |
p. 1203-1213.e13
|
artikel
|
| 35 |
Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
|
Sumi, Natalia J.
|
|
2019
|
|
9 |
p. 1240-1252.e11
|
artikel
|
| 36 |
Drug Discovery and Chemical Biology of Cancer Epigenetics
|
Ribich, Scott
|
|
2017
|
|
9 |
p. 1120-1147
28 p.
|
artikel
|
| 37 |
Emerging Opportunities for Target Discovery in Rare Cancers
|
Sharifnia, Tanaz
|
|
2017
|
|
9 |
p. 1075-1091
17 p.
|
artikel
|
| 38 |
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification
|
Povedano, Juan Manuel
|
|
2019
|
|
9 |
p. 1315-1321.e3
|
artikel
|
| 39 |
Ferroptosis execution: Is it all about ACSL4?
|
Lee, Hyemin
|
|
|
|
9 |
p. 1363-1365
|
artikel
|
| 40 |
For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill
|
Shami Shah, Adnan
|
|
|
|
9 |
p. 1114-1116
|
artikel
|
| 41 |
Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport
|
Cross, Jessica A.
|
|
|
|
9 |
p. 1347-1355.e5
|
artikel
|
| 42 |
From Catalytic Antibodies to Antibody-Drug Conjugates
|
Dimitrov, Dimiter S.
|
|
2019
|
|
9 |
p. 1200-1201
|
artikel
|
| 43 |
Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes
|
Ji, Xing
|
|
|
|
9 |
p. 1053-1063.e5
|
artikel
|
| 44 |
Genetically Encoded Protein Phosphorylation in Mammalian Cells
|
Beránek, Václav
|
|
2018
|
|
9 |
p. 1067-1074.e5
|
artikel
|
| 45 |
Glutamine availability unleashes dendritic cells’ anti-tumor power
|
Corrado, Mauro
|
|
|
|
9 |
p. 1012-1014
|
artikel
|
| 46 |
How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing
|
Zhang, Junbing
|
|
2019
|
|
9 |
p. 1195-1196
|
artikel
|
| 47 |
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
|
Spangenberg, Stephan H.
|
|
|
|
9 |
p. 1115-1134.e10
|
artikel
|
| 48 |
Hypoxia-activated KDAC inhibitor: Taking a breath from untargeted therapy
|
Staudt, Maximilian
|
|
|
|
9 |
p. 1255-1257
|
artikel
|
| 49 |
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
|
Hendricks, Joseph M.
|
|
|
|
9 |
p. 1090-1103.e7
|
artikel
|
| 50 |
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
|
Simpson, Luke M.
|
|
|
|
9 |
p. 1164-1180.e5
|
artikel
|
| 51 |
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide
|
Payne, Sterling R.
|
|
2018
|
|
9 |
p. 1059-1066.e4
|
artikel
|
| 52 |
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
|
Reckzeh, Elena S.
|
|
2019
|
|
9 |
p. 1214-1228.e25
|
artikel
|
| 53 |
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers
|
Malishev, Ravit
|
|
|
|
9 |
p. 1310-1320.e5
|
artikel
|
| 54 |
In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling
|
Hong, Senlian
|
|
|
|
9 |
p. 1140-1150.e4
|
artikel
|
| 55 |
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis
|
Yu, Shan
|
|
|
|
9 |
p. 1169-1182.e8
|
artikel
|
| 56 |
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates
|
Trivedi, Vikas D.
|
|
|
|
9 |
p. 1135-1143.e5
|
artikel
|
| 57 |
In This Issue
|
|
|
2016
|
|
9 |
p. v-vii
nvt p.
|
artikel
|
| 58 |
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
|
Chu, Lianhe
|
|
|
|
9 |
p. 1368-1380.e5
|
artikel
|
| 59 |
It Takes a Megalopolis to Relaunch a Journal: A Story of Gratitude
|
Kostic, Milka
|
|
2016
|
|
9 |
p. 1037-1038
2 p.
|
artikel
|
| 60 |
Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum
|
Plowright, Alleyn T.
|
|
2017
|
|
9 |
p. 1058-1065
8 p.
|
artikel
|
| 61 |
Lipase Processing of Complex Lipid Antigens
|
Sander, Peter
|
|
2016
|
|
9 |
p. 1044-1046
3 p.
|
artikel
|
| 62 |
Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens
|
Gilleron, Martine
|
|
2016
|
|
9 |
p. 1147-1156
10 p.
|
artikel
|
| 63 |
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy
|
Hazama, Daisuke
|
|
|
|
9 |
p. 1181-1191.e7
|
artikel
|
| 64 |
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors
|
Weigt, David
|
|
2019
|
|
9 |
p. 1322-1331.e4
|
artikel
|
| 65 |
Metabolic and chemical architecture of the mammalian circadian clock
|
Laothamatas, Isara
|
|
|
|
9 |
p. 1033-1052
|
artikel
|
| 66 |
Metabolic modulation of mitochondrial mass during CD4+ T cell activation
|
Kurmi, Kiran
|
|
|
|
9 |
p. 1064-1075.e8
|
artikel
|
| 67 |
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
|
Dawson, Christopher D.
|
|
|
|
9 |
p. 1333-1346.e7
|
artikel
|
| 68 |
Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity
|
Saghatelian, Alan
|
|
|
|
9 |
p. 1112-1113
|
artikel
|
| 69 |
NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes
|
De Jesus, Dario F.
|
|
|
|
9 |
p. 1144-1155.e4
|
artikel
|
| 70 |
N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis
|
Martelli, Giulia
|
|
|
|
9 |
p. 1321-1332.e5
|
artikel
|
| 71 |
Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries
|
Mehta, Akul Y.
|
|
|
|
9 |
p. 1207-1219.e9
|
artikel
|
| 72 |
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
|
Larraufie, Marie-Hélène
|
|
|
|
9 |
p. 1271-1282.e12
|
artikel
|
| 73 |
6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels
|
Li, Haoxin
|
|
2019
|
|
9 |
p. 1306-1314.e5
|
artikel
|
| 74 |
Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides
|
Keenan, Tessa
|
|
|
|
9 |
p. 1199-1206.e5
|
artikel
|
| 75 |
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis
|
Pradhan, Apoorva J.
|
|
|
|
9 |
p. 1298-1309.e7
|
artikel
|
| 76 |
Regulation of Autophagic Flux by the 20S Proteasome
|
Njomen, Evert
|
|
2019
|
|
9 |
p. 1283-1294.e5
|
artikel
|
| 77 |
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer
|
Wang, Yiyang
|
|
|
|
9 |
p. 1283-1297.e8
|
artikel
|
| 78 |
Remembering Professor Amy Christine Anderson
|
Schiffer, Celia
|
|
2016
|
|
9 |
p. 1041-1042
2 p.
|
artikel
|
| 79 |
Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY!
|
Certo, Michelangelo
|
|
|
|
9 |
p. 1009-1011
|
artikel
|
| 80 |
Resistance to Enediyne Antitumor Antibiotics by Sequestration
|
Chang, Chin-Yuan
|
|
2018
|
|
9 |
p. 1075-1085.e4
|
artikel
|
| 81 |
Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors
|
Xavier da Silva, Thamara Nishida
|
|
|
|
9 |
p. 1006-1008
|
artikel
|
| 82 |
Screening in serum-derived medium reveals differential response to compounds targeting metabolism
|
Abbott, Keene L.
|
|
|
|
9 |
p. 1156-1168.e7
|
artikel
|
| 83 |
Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors
|
Huhn, Annissa J.
|
|
2016
|
|
9 |
p. 1123-1134
12 p.
|
artikel
|
| 84 |
Sequencing Mirror-Image DNA Chemically
|
Liu, Xianyu
|
|
2018
|
|
9 |
p. 1151-1156.e3
|
artikel
|
| 85 |
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
|
Hwang, Dobeen
|
|
2019
|
|
9 |
p. 1229-1239.e9
|
artikel
|
| 86 |
Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy
|
Hengel, Sarah R.
|
|
2017
|
|
9 |
p. 1101-1119
19 p.
|
artikel
|
| 87 |
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism
|
Huang, Ling
|
|
|
|
9 |
p. 1076-1089.e11
|
artikel
|
| 88 |
Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling
|
Diviani, Dario
|
|
2016
|
|
9 |
p. 1135-1146
12 p.
|
artikel
|
| 89 |
Small-Molecule Targets in Immuno-Oncology
|
Dhanak, Dashyant
|
|
2017
|
|
9 |
p. 1148-1160
13 p.
|
artikel
|
| 90 |
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1
|
Jun, Yong Woong
|
|
|
|
9 |
p. 1117-1123
|
artikel
|
| 91 |
Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation
|
Yoshimoto, Rei
|
|
|
|
9 |
p. 1356-1365.e4
|
artikel
|
| 92 |
Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator
|
Luo, Xiaozhou
|
|
2016
|
|
9 |
p. 1098-1102
5 p.
|
artikel
|
| 93 |
Starving the Devourer: Cutting Cancer Off from Its Favorite Foods
|
Katt, William P.
|
|
2019
|
|
9 |
p. 1197-1199
|
artikel
|
| 94 |
Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles
|
Aleem, Saadat U.
|
|
2016
|
|
9 |
p. 1103-1112
10 p.
|
artikel
|
| 95 |
Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR
|
O'Reilly, Matthew C.
|
|
2018
|
|
9 |
p. 1128-1139.e3
|
artikel
|
| 96 |
Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations
|
Lee, Samuel K.
|
|
2016
|
|
9 |
p. 1157-1169
13 p.
|
artikel
|
| 97 |
Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate
|
Schäfer, Martin
|
|
2016
|
|
9 |
p. 1091-1097
7 p.
|
artikel
|
| 98 |
Synthetic Biology-Based Point-of-Care Diagnostics for Infectious Disease
|
Wei, Ting-Yen
|
|
2016
|
|
9 |
p. 1056-1066
11 p.
|
artikel
|
| 99 |
Systematic Chemogenetic Library Assembly
|
Canham, Stephen M.
|
|
|
|
9 |
p. 1124-1129
|
artikel
|
| 100 |
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
|
Cromm, Philipp M.
|
|
2017
|
|
9 |
p. 1181-1190
10 p.
|
artikel
|
| 101 |
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
|
Röth, Sascha
|
|
|
|
9 |
p. 1151-1163.e6
|
artikel
|
| 102 |
Targeting Metabolism for Cancer Therapy
|
Luengo, Alba
|
|
2017
|
|
9 |
p. 1161-1180
20 p.
|
artikel
|
| 103 |
Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer
|
Lim, Kee Siang
|
|
2018
|
|
9 |
p. 1056-1058
|
artikel
|
| 104 |
The Emerging Role of RNA as a Therapeutic Target for Small Molecules
|
Connelly, Colleen M.
|
|
2016
|
|
9 |
p. 1077-1090
14 p.
|
artikel
|
| 105 |
The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway
|
De Cesare, Virginia
|
|
2018
|
|
9 |
p. 1117-1127.e4
|
artikel
|
| 106 |
The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1
|
Pearson, Russell J.
|
|
2018
|
|
9 |
p. 1107-1116.e4
|
artikel
|
| 107 |
The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens
|
Williams, Steven P.
|
|
2017
|
|
9 |
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