nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
1 |
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
|
Shao, Hao |
|
|
|
8 |
p. 1303-1316.e3 |
artikel |
2 |
Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation
|
Fuhrmann, Jakob |
|
2016 |
|
8 |
p. 967-977 11 p. |
artikel |
3 |
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity
|
Xiao, Lu |
|
|
|
8 |
p. 1341-1352.e8 |
artikel |
4 |
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
|
Wong, Keith S. |
|
|
|
8 |
p. 1017-1030.e9 |
artikel |
5 |
Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes
|
Rakers, Lena |
|
|
|
8 |
p. 952-961.e12 |
artikel |
6 |
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader
|
Payne, N. Connor |
|
|
|
8 |
p. 1333-1340.e5 |
artikel |
7 |
A Fungal-Selective Cytochrome bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance
|
Vincent, Benjamin M. |
|
2016 |
|
8 |
p. 978-991 14 p. |
artikel |
8 |
Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides
|
Haney, Evan F. |
|
2017 |
|
8 |
p. 969-980.e4 |
artikel |
9 |
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
|
Ferguson, Ian D. |
|
|
|
8 |
p. 1288-1302.e7 |
artikel |
10 |
Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction
|
Jacobsen, Michael T. |
|
2017 |
|
8 |
p. 1040-1047.e4 |
artikel |
11 |
An antitubercular prodrug leaves Mycobacterium tuberculosis facing a difficult choice, poisoning or starvation?
|
Jackson, Mary |
|
|
|
8 |
p. 1101-1103 |
artikel |
12 |
A non-rational approach to optimized targeting of CRISPR-Cas9 complexes
|
Wilbanks, Brandon |
|
|
|
8 |
p. 855-857 |
artikel |
13 |
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
|
Jelcic, Mark |
|
|
|
8 |
p. 1073-1083.e12 |
artikel |
14 |
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants
|
Schenkel, Laurie B. |
|
|
|
8 |
p. 1158-1168.e13 |
artikel |
15 |
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
|
Birnbaum, Michael D. |
|
|
|
8 |
p. 1038-1049.e5 |
artikel |
16 |
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
|
Chatrikhi, Rakesh |
|
|
|
8 |
p. 1145-1157.e6 |
artikel |
17 |
A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
|
Huang, Yujie |
|
2019 |
|
8 |
p. 1143-1158.e6 |
artikel |
18 |
Basis of Mutual Domain Inhibition in a Bacterial Response Regulator
|
Corrêa, Fernando |
|
2016 |
|
8 |
p. 945-954 10 p. |
artikel |
19 |
Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence
|
Sjekloća, Ljiljana |
|
2019 |
|
8 |
p. 1159-1168.e4 |
artikel |
20 |
Bioreporters for direct mode of action-informed screening of antibiotic producer strains
|
Wex, Katharina W. |
|
|
|
8 |
p. 1242-1252.e4 |
artikel |
21 |
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
|
Zhang, Qian |
|
|
|
8 |
p. 1248-1259.e6 |
artikel |
22 |
Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
|
Dietrich, Laura |
|
2017 |
|
8 |
p. 958-968.e5 |
artikel |
23 |
Chemical Biology Interrogates Protein Arginine Phosphorylation
|
Suskiewicz, Marcin Józef |
|
2016 |
|
8 |
p. 888-890 3 p. |
artikel |
24 |
Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
|
Huey, Julia |
|
|
|
8 |
p. 1015-1031 |
artikel |
25 |
Chemical Biology Tools for Examining the Bacterial Cell Wall
|
Brown, Ashley R. |
|
|
|
8 |
p. 1052-1062 |
artikel |
26 |
Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine
|
Liu, Kai |
|
2016 |
|
8 |
p. 893-916 24 p. |
artikel |
27 |
Chemical Tools for Endogenous Protein Labeling and Profiling
|
Shiraiwa, Kazuki |
|
|
|
8 |
p. 970-985 |
artikel |
28 |
Chemical Tools in Biological Discovery
|
Dey, Mishtu |
|
|
|
8 |
p. 889-890 |
artikel |
29 |
Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
|
Goth, Christoffer K. |
|
|
|
8 |
p. 893-905.e7 |
artikel |
30 |
Construction of Fluorescent Analogs to Follow the Uptake and Distribution of Cobalamin (Vitamin B12) in Bacteria, Worms, and Plants
|
Lawrence, Andrew D. |
|
|
|
8 |
p. 941-951.e6 |
artikel |
31 |
Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators
|
Bachas, Sharrol T. |
|
|
|
8 |
p. 962-973.e5 |
artikel |
32 |
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes
|
Poreba, Marcin |
|
2016 |
|
8 |
p. 1023-1035 13 p. |
artikel |
33 |
Deciphering Carbamoylpolyoxamic Acid Biosynthesis Reveals Unusual Acetylation Cycle Associated with Tandem Reduction and Sequential Hydroxylation
|
Qi, Jianzhao |
|
2016 |
|
8 |
p. 935-944 10 p. |
artikel |
34 |
DELs enable the development of BRET probes for target engagement studies in cells
|
Teske, Kelly A. |
|
|
|
8 |
p. 987-998.e24 |
artikel |
35 |
Dual pH/Activity Probes Expand the Cathepsin Toolkit
|
Shin, Sunny |
|
2016 |
|
8 |
p. 891-892 2 p. |
artikel |
36 |
Dysregulating ClpP: From Antibiotics to Anticancer?
|
Dougan, David A. |
|
|
|
8 |
p. 929-930 |
artikel |
37 |
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs
|
Khandelwal, Neha |
|
|
|
8 |
p. 1169-1179.e6 |
artikel |
38 |
Fighting Kinase Drug Resistance with Caspase Activators
|
Hardy, Jeanne A. |
|
|
|
8 |
p. 927-928 |
artikel |
39 |
From Powerful Review Articles to Research Breakthroughs
|
Kostic, Milka |
|
2016 |
|
8 |
p. 883-884 2 p. |
artikel |
40 |
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
|
Müller, Martin |
|
|
|
8 |
p. 1119-1131.e27 |
artikel |
41 |
Generation of glycan-specific nanobodies
|
Khilji, Sana Khan |
|
|
|
8 |
p. 1353-1361.e6 |
artikel |
42 |
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase
|
Böhringer, Nils |
|
|
|
8 |
p. 943-952.e7 |
artikel |
43 |
Genome editor-directed in vivo library diversification
|
Cheng, Cristina |
|
|
|
8 |
p. 1109-1118 |
artikel |
44 |
Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity
|
Martell, Julianne |
|
2016 |
|
8 |
p. 955-966 12 p. |
artikel |
45 |
Help! I need a WNT antibody. Help! Not just any antibody
|
Maimets, Martti |
|
|
|
8 |
p. 857-860 |
artikel |
46 |
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells
|
Braselmann, Esther |
|
|
|
8 |
p. 891-903 |
artikel |
47 |
Improved ThwaRTing of Genome Symbionts
|
Goodier, John L. |
|
2019 |
|
8 |
p. 1043-1045 |
artikel |
48 |
In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking
|
Kudriaeva, Anna A. |
|
|
|
8 |
p. 1192-1205.e9 |
artikel |
49 |
Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein
|
de Wispelaere, Melissanne |
|
|
|
8 |
p. 1006-1016.e8 |
artikel |
50 |
Inhibition of nucleolar transcription by oxaliplatin involves ATM/ATR kinase signaling
|
Nechay, Misha |
|
|
|
8 |
p. 906-919.e4 |
artikel |
51 |
Inside Job: Methods for Delivering Proteins to the Interior of Mammalian Cells
|
Bruce, Virginia J. |
|
2017 |
|
8 |
p. 924-934 |
artikel |
52 |
Insulin sensitization by small molecules enhancing GLUT4 translocation
|
Yin, Terry C. |
|
|
|
8 |
p. 933-942.e6 |
artikel |
53 |
In This Issue
|
|
|
2016 |
|
8 |
p. v-vii nvt p. |
artikel |
54 |
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming
|
Vinogradov, Alexander A. |
|
|
|
8 |
p. 1032-1051 |
artikel |
55 |
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis
|
Salomón, Trine |
|
2017 |
|
8 |
p. 935-943.e7 |
artikel |
56 |
Lanthanide-Based Optical Probes of Biological Systems
|
Cho, Ukrae |
|
|
|
8 |
p. 921-936 |
artikel |
57 |
Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
|
Geng, Chen-Lu |
|
|
|
8 |
p. 1260-1272.e8 |
artikel |
58 |
Mitochondrial Chemical Biology: New Probes Elucidate the Secrets of the Powerhouse of the Cell
|
Wisnovsky, Simon |
|
2016 |
|
8 |
p. 917-927 11 p. |
artikel |
59 |
Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration
|
Somalo-Barranco, Gloria |
|
|
|
8 |
p. 920-932.e7 |
artikel |
60 |
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
|
Narvaez, Ana J. |
|
2017 |
|
8 |
p. 1017-1028.e7 |
artikel |
61 |
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
|
Hafner, Marc |
|
2019 |
|
8 |
p. 1067-1080.e8 |
artikel |
62 |
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
|
Post, Yorick |
|
|
|
8 |
p. 976-986.e5 |
artikel |
63 |
Optimized Streptavidin for Fluorescent Labeling of Biotinylated Targets
|
Hytönen, Vesa P. |
|
2017 |
|
8 |
p. 921-922 |
artikel |
64 |
OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity
|
Rovira, Xavier |
|
2016 |
|
8 |
p. 929-934 6 p. |
artikel |
65 |
Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
|
Peh, Jessie |
|
|
|
8 |
p. 996-1005.e4 |
artikel |
66 |
Parallel Chemoselective Profiling for Mapping Protein Structure
|
Potter, Zachary E. |
|
|
|
8 |
p. 1084-1096.e4 |
artikel |
67 |
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
|
Dvorak, Vojtech |
|
|
|
8 |
p. 953-964.e9 |
artikel |
68 |
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin
|
Zhu, Huifang |
|
2019 |
|
8 |
p. 1122-1132.e6 |
artikel |
69 |
Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents
|
Kim, Hyung Jun |
|
|
|
8 |
p. 1317-1324.e5 |
artikel |
70 |
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
|
Zeng, Mei |
|
2017 |
|
8 |
p. 1005-1016.e3 |
artikel |
71 |
Principles of Chemical Biology: Iron and CSCs, Histone Acylation sans Enzymes, Eliciting Silent Gene Clusters, and 2′-deoxy-ADPR as a Second Messenger
|
|
|
2017 |
|
8 |
p. 919-920 |
artikel |
72 |
Programming Cell-Cell Interactions through Non-genetic Membrane Engineering
|
Csizmar, Clifford M. |
|
|
|
8 |
p. 931-940 |
artikel |
73 |
PROTACs: An Emerging Therapeutic Modality in Precision Medicine
|
Nalawansha, Dhanusha A. |
|
|
|
8 |
p. 998-1014 |
artikel |
74 |
Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products
|
Xu, Jun-Yu |
|
|
|
8 |
p. 984-995.e6 |
artikel |
75 |
Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
|
Makafe, Gaelle G. |
|
2019 |
|
8 |
p. 1187-1194.e5 |
artikel |
76 |
Rapid Screening and Identification of Living Pathogenic Organisms via Optimized Bioorthogonal Non-canonical Amino Acid Tagging
|
Sherratt, Allison Rae |
|
2017 |
|
8 |
p. 1048-1055.e3 |
artikel |
77 |
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems
|
Binns, Thomas C. |
|
|
|
8 |
p. 1063-1072.e7 |
artikel |
78 |
Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria
|
Halloy, François |
|
|
|
8 |
p. 1221-1234.e6 |
artikel |
79 |
Repurposing the repurposed: thalidomide analogs as immune stimulants to overcome T cell exhaustion
|
Słabicki, Mikołaj |
|
|
|
8 |
p. 1245-1247 |
artikel |
80 |
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis
|
Libardo, M. Daben J. |
|
|
|
8 |
p. 1180-1191.e20 |
artikel |
81 |
RIBOTACs: Small Molecules Target RNA for Degradation
|
Dey, Sourav K. |
|
2019 |
|
8 |
p. 1047-1049 |
artikel |
82 |
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation
|
Zhao, Dongyu |
|
|
|
8 |
p. 1235-1241.e5 |
artikel |
83 |
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology
|
Love, Anna C. |
|
|
|
8 |
p. 904-920 |
artikel |
84 |
Selective Modulation of Dynamic Protein Complexes
|
Garlick, Julie M. |
|
|
|
8 |
p. 986-997 |
artikel |
85 |
Shedding Light on Metabotropic Glutamate Receptors
|
Nicoletti, Ferdinando |
|
2016 |
|
8 |
p. 887-888 2 p. |
artikel |
86 |
Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death
|
Song, Jin H. |
|
2019 |
|
8 |
p. 1110-1121.e4 |
artikel |
87 |
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
|
Doulias, Paschalis-Thomas |
|
|
|
8 |
p. 965-975.e6 |
artikel |
88 |
S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
|
Toyomoto, Masayasu |
|
|
|
8 |
p. 1132-1144.e9 |
artikel |
89 |
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy
|
Young, Zapporah T. |
|
2016 |
|
8 |
p. 992-1001 10 p. |
artikel |
90 |
Stem Cell Hydrogel, Jump-Starting Zika Drug Discovery, and Engineering RNA Recognition
|
Kostic, Milka |
|
2016 |
|
8 |
p. 885-886 2 p. |
artikel |
91 |
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases
|
Faucher, Franco |
|
|
|
8 |
p. 937-952 |
artikel |
92 |
Structure-based Engineering of a Plant-Fungal Hybrid Peroxidase for Enhanced Temperature and pH Tolerance
|
Kohler, Amanda C. |
|
|
|
8 |
p. 974-983.e3 |
artikel |
93 |
Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus
|
Zheng, Weihao |
|
2016 |
|
8 |
p. 1002-1013 12 p. |
artikel |
94 |
Stuck on UUUU: New splicing inhibitors enhance U2AF2-RNA binding
|
Love, Sierra L. |
|
|
|
8 |
p. 1106-1108 |
artikel |
95 |
Switching Off Cancer-Causing Telomerase Using Small Molecules
|
Asamitsu, Sefan |
|
2019 |
|
8 |
p. 1045-1047 |
artikel |
96 |
Synthesis and Characterization of Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons
|
Banuelos-Sanchez, Guillermo |
|
2019 |
|
8 |
p. 1095-1109.e14 |
artikel |
97 |
Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections
|
Broecker, Felix |
|
2016 |
|
8 |
p. 1014-1022 9 p. |
artikel |
98 |
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease
|
Totzke, Juliane |
|
2017 |
|
8 |
p. 1029-1039.e7 |
artikel |
99 |
Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics
|
Guardiola, Salvador |
|
|
|
8 |
p. 1031-1037.e4 |
artikel |
100 |
Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA
|
Costales, Matthew G. |
|
2019 |
|
8 |
p. 1180-1186.e5 |
artikel |
101 |
Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics
|
Coulson, Garry B. |
|
2017 |
|
8 |
p. 993-1004.e4 |
artikel |
102 |
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
|
Mehta, Stuti |
|
|
|
8 |
p. 1273-1287.e8 |
artikel |
103 |
The Chemical Biology of Reversible Lysine Post-translational Modifications
|
Wang, Zhipeng A. |
|
|
|
8 |
p. 953-969 |
artikel |
104 |
The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery
|
Friese, Alexandra |
|
2019 |
|
8 |
p. 1050-1066 |
artikel |
105 |
The dark side of circular RNA, a new driver of genome instability
|
Sharma, Ajit Kumar |
|
|
|
8 |
p. 861-863 |
artikel |
106 |
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines
|
Gardner, Nicola J. |
|
2017 |
|
8 |
p. 981-992.e4 |
artikel |
107 |
The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
|
Matarlo, Joe S. |
|
2019 |
|
8 |
p. 1133-1142.e4 |
artikel |
108 |
The rise of degrader drugs
|
Teng, Mingxing |
|
|
|
8 |
p. 864-878 |
artikel |
109 |
Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response
|
Klomp, Jennifer E. |
|
2019 |
|
8 |
p. 1081-1094.e6 |
artikel |
110 |
TK216 targets microtubules in Ewing sarcoma cells
|
Povedano, Juan Manuel |
|
|
|
8 |
p. 1325-1332.e4 |
artikel |
111 |
Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A
|
Maurer, Michael |
|
2019 |
|
8 |
p. 1169-1179.e4 |
artikel |
112 |
TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer
|
Alharbi, Abeer F. |
|
|
|
8 |
p. 1103-1105 |
artikel |
113 |
β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling
|
Long, Marcus John |
|
2017 |
|
8 |
p. 944-957.e7 |
artikel |
114 |
Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome
|
Furkert, David |
|
|
|
8 |
p. 1097-1108.e4 |
artikel |
115 |
Utilizing directed evolution to interrogate and optimize CRISPR/Cas guide RNA scaffolds
|
Bush, Korie |
|
|
|
8 |
p. 879-892.e5 |
artikel |
116 |
Wanted Alive: Finding Bacteria in Your Food
|
Kawamura, Akira |
|
2017 |
|
8 |
p. 922-923 |
artikel |
117 |
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer
|
Tailor, Dhanir |
|
|
|
8 |
p. 1206-1220.e6 |
artikel |