| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders
|
Yang, Ka
|
|
|
|
7 |
p. 866-876.e8
|
artikel
|
| 2 |
A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast
|
Li, Yi
|
|
|
|
7 |
p. 858-865.e8
|
artikel
|
| 3 |
Advances and opportunities in targeted protein degradation
|
Nomura, Daniel K.
|
|
|
|
7 |
p. 887-888
|
artikel
|
| 4 |
Allosteric Regulation of Oligomerization by a B12 Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria
|
Ruetz, Markus
|
|
2019
|
|
7 |
p. 960-969.e4
|
artikel
|
| 5 |
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation
|
Jevtić, Predrag
|
|
|
|
7 |
p. 1000-1013
|
artikel
|
| 6 |
A phospholipid mimetic targeting LRH-1 ameliorates colitis
|
Mays, Suzanne G.
|
|
|
|
7 |
p. 1174-1186.e7
|
artikel
|
| 7 |
A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress
|
Trist, Benjamin Guy
|
|
2018
|
|
7 |
p. 807-816
|
artikel
|
| 8 |
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin
|
Murray, Ewan J.
|
|
|
|
7 |
p. 1187-1199.e6
|
artikel
|
| 9 |
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
|
Berton, Stefania
|
|
|
|
7 |
p. 1126-1139.e12
|
artikel
|
| 10 |
A “Smart Lock” for Preventing Hepatitis B Entry into Cells
|
Balzarini, Madeline
|
|
2018
|
|
7 |
p. 804-806
|
artikel
|
| 11 |
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity
|
Ganley, Jack G.
|
|
|
|
7 |
p. 817-826.e5
|
artikel
|
| 12 |
At Long Last Potent and Selective KDM5 Inhibitors
|
Rotili, Dante
|
|
2016
|
|
7 |
p. 749-751
|
artikel
|
| 13 |
Attenuating Staphylococcus aureus Virulence by Targeting Flotillin Protein Scaffold Activity
|
Koch, Gudrun
|
|
2017
|
|
7 |
p. 845-857.e6
8.56999156E8 p.
|
artikel
|
| 14 |
Bifunctional modalities for repurposing protein function
|
Modell, Ashley E.
|
|
|
|
7 |
p. 1081-1089
|
artikel
|
| 15 |
Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection
|
Sanman, Laura E.
|
|
2016
|
|
7 |
p. 793-804
|
artikel
|
| 16 |
Catalytic spike antibodies: A new paradigm in neutralization
|
McNamara, Ryan P.
|
|
|
|
7 |
p. 701-702
|
artikel
|
| 17 |
Catch Shiny Droplets in Suspension—Finding the Needle in a Haystack
|
Hein-Fuchs, Nina V.
|
|
2017
|
|
7 |
p. 783-784
2 p.
|
artikel
|
| 18 |
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells
|
Zhang, Rukang
|
|
|
|
7 |
p. 1200-1208.e6
|
artikel
|
| 19 |
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
|
Orlando, Luca
|
|
|
|
7 |
p. 780-794.e8
|
artikel
|
| 20 |
Chemical insights into flexizyme-mediated tRNA acylation
|
Coronado, Jaime N.
|
|
|
|
7 |
p. 1071-1112
|
artikel
|
| 21 |
Chemical Tools for Studying TLR Signaling Dynamics
|
Oosenbrug, Timo
|
|
2017
|
|
7 |
p. 801-812
12 p.
|
artikel
|
| 22 |
Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1
|
Mitchell, Dylan C.
|
|
2019
|
|
7 |
p. 980-990.e8
|
artikel
|
| 23 |
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1
|
Hu, Zongyi
|
|
|
|
7 |
p. 780-792.e5
|
artikel
|
| 24 |
Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis
|
Vögeli, Bastian
|
|
2018
|
|
7 |
p. 833-839.e4
|
artikel
|
| 25 |
Crystal Structure of a Group I Energy Coupling Factor Vitamin Transporter S Component in Complex with Its Cognate Substrate
|
Josts, Inokentijs
|
|
2016
|
|
7 |
p. 827-836
|
artikel
|
| 26 |
Decoding the messaging of the ubiquitin system using chemical and protein probes
|
Henneberg, Lukas T.
|
|
|
|
7 |
p. 889-902
|
artikel
|
| 27 |
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway
|
Ahn, Green
|
|
|
|
7 |
p. 1072-1080
|
artikel
|
| 28 |
De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry
|
Passioura, Toby
|
|
2018
|
|
7 |
p. 906-915.e5
|
artikel
|
| 29 |
Development and Application of a High-Throughput Functional Metagenomic Screen for Glycoside Phosphorylases
|
Macdonald, Spencer S.
|
|
2019
|
|
7 |
p. 1001-1012.e5
|
artikel
|
| 30 |
Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8+ T Cell Priming Capacity of Dendritic Cells
|
Shin, Myungsun
|
|
2019
|
|
7 |
p. 1036-1041.e3
|
artikel
|
| 31 |
Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β
|
Cook, Brandoch
|
|
2019
|
|
7 |
p. 926-935.e6
|
artikel
|
| 32 |
Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells
|
Pisa, Rudolf
|
|
|
|
7 |
p. 850-857.e6
|
artikel
|
| 33 |
Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
|
Chennamadhavuni, Divya
|
|
2018
|
|
7 |
p. 925
|
artikel
|
| 34 |
Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery
|
Wang, Yuan
|
|
2016
|
|
7 |
p. 862-874
|
artikel
|
| 35 |
Evidence that HDAC7 acts as an epigenetic “reader” of AR acetylation through NCoR-HDAC3 dissociation
|
Zhang, Yuchen
|
|
|
|
7 |
p. 1162-1173.e5
|
artikel
|
| 36 |
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
|
Kannt, Aimo
|
|
|
|
7 |
p. 1014-1031
|
artikel
|
| 37 |
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology
|
Ito, Takumi
|
|
|
|
7 |
p. 987-999
|
artikel
|
| 38 |
Fake Inhibitors: AMPK Activation Trumps Inhibition
|
Langendorf, Christopher G.
|
|
2017
|
|
7 |
p. 775-777
3 p.
|
artikel
|
| 39 |
Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement
|
Gao, Guixi
|
|
2017
|
|
7 |
p. 881-891.e4
8.90912E6 p.
|
artikel
|
| 40 |
From Young to Old: AMPylation Hits the Brain
|
Sieber, Stephan A.
|
|
|
|
7 |
p. 773-779
|
artikel
|
| 41 |
Haven't got a glue: Protein surface variation for the design of molecular glue degraders
|
Kozicka, Zuzanna
|
|
|
|
7 |
p. 1032-1047
|
artikel
|
| 42 |
High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery
|
Kizuka, Yasuhiko
|
|
2016
|
|
7 |
p. 782-792
|
artikel
|
| 43 |
Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase
|
Moreno-Yruela, Carlos
|
|
2018
|
|
7 |
p. 849-856.e8
|
artikel
|
| 44 |
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
|
Scholes, Natalie S.
|
|
|
|
7 |
p. 1048-1060
|
artikel
|
| 45 |
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity
|
Iyer, Kali R.
|
|
|
|
7 |
p. 795-810.e8
|
artikel
|
| 46 |
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses
|
Maarifi, Ghizlane
|
|
|
|
7 |
p. 1113-1125.e6
|
artikel
|
| 47 |
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
|
Vanaerschot, Manu
|
|
|
|
7 |
p. 806-816.e8
|
artikel
|
| 48 |
Innovative Strategies for Selective Inhibition of Histone Deacetylases
|
Maolanon, Alex R.
|
|
2016
|
|
7 |
p. 759-768
|
artikel
|
| 49 |
Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases
|
Wang, Ya-Juan
|
|
2019
|
|
7 |
p. 909-910
|
artikel
|
| 50 |
In This Issue
|
|
|
2016
|
|
7 |
p. v-vii
|
artikel
|
| 51 |
Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry
|
Chen, Fang
|
|
|
|
7 |
p. 767-769
|
artikel
|
| 52 |
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement
|
Wigle, Tim J.
|
|
|
|
7 |
p. 877-887.e14
|
artikel
|
| 53 |
Itaconate and Inflammation, miRs in Zebrafish Embryos, and SHP2 Inhibitor
|
|
|
2016
|
|
7 |
p. 747-748
|
artikel
|
| 54 |
Lighting the way to host-directed immunotherapeutics
|
van Tol, Sarah
|
|
|
|
7 |
p. 1067-1070
|
artikel
|
| 55 |
Lipid Modulation of Membrane Protein Function
|
Whitelegge, Julian
|
|
2018
|
|
7 |
p. 803-804
|
artikel
|
| 56 |
Measuring Endoplasmic Reticulum Signal Sequences Translocation Efficiency Using the Xbp1 Arrest Peptide
|
Kriegler, Theresa
|
|
2018
|
|
7 |
p. 880-890.e3
|
artikel
|
| 57 |
Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR
|
Sinclair, Julie K.L.
|
|
2018
|
|
7 |
p. 857-870.e7
|
artikel
|
| 58 |
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
|
Ross, Fiona A.
|
|
2017
|
|
7 |
p. 813-824.e4
8.239188E6 p.
|
artikel
|
| 59 |
Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators
|
Shah, Falgun
|
|
2017
|
|
7 |
p. 858-869.e5
8.6899143E7 p.
|
artikel
|
| 60 |
Metabolic incorporation of electron-rich ribonucleosides enhances APEX-seq for profiling spatially restricted nascent transcriptome
|
Li, Ran
|
|
|
|
7 |
p. 1218-1231.e8
|
artikel
|
| 61 |
Mining Proteomes Using Bioorthogonal Probes
|
Wu, Haoxing
|
|
2016
|
|
7 |
p. 751-753
|
artikel
|
| 62 |
Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
|
Truong, Thu H.
|
|
2016
|
|
7 |
p. 837-848
|
artikel
|
| 63 |
Molecular Basis of Mannose Recognition by Pradimicins and their Application to Microbial Cell Surface Imaging
|
Nakagawa, Yu
|
|
2019
|
|
7 |
p. 950-959.e8
|
artikel
|
| 64 |
Morphological subprofile analysis for bioactivity annotation of small molecules
|
Pahl, Axel
|
|
|
|
7 |
p. 839-853.e7
|
artikel
|
| 65 |
Native chemical ligation approach to sensitively probe tissue acyl-CoA pools
|
James, Andrew M.
|
|
|
|
7 |
p. 1232-1244.e5
|
artikel
|
| 66 |
No Bones About It: Small Molecules for Bone Regeneration
|
Chang, Jae Won
|
|
2019
|
|
7 |
p. 911-912
|
artikel
|
| 67 |
Optical control of targeted protein degradation
|
Reynders, Martin
|
|
|
|
7 |
p. 969-986
|
artikel
|
| 68 |
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
|
Berdan, Charles A.
|
|
2019
|
|
7 |
p. 1027-1035.e22
|
artikel
|
| 69 |
Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes
|
Lee, Michael H.
|
|
|
|
7 |
p. 765-767
|
artikel
|
| 70 |
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
|
Fischer, Sabrina
|
|
|
|
7 |
p. 766-779.e11
|
artikel
|
| 71 |
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia
|
Sondo, Elvira
|
|
2018
|
|
7 |
p. 891-905.e8
|
artikel
|
| 72 |
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets
|
Gautam, Prson
|
|
2019
|
|
7 |
p. 970-979.e4
|
artikel
|
| 73 |
PI(4,5)P2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in β Cells
|
Suh, Byung-Chang
|
|
2016
|
|
7 |
p. 753-755
|
artikel
|
| 74 |
Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic β Cells
|
Xie, Beichen
|
|
2016
|
|
7 |
p. 816-826
|
artikel
|
| 75 |
Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance
|
Real, Alexander M.
|
|
|
|
7 |
p. 770-772
|
artikel
|
| 76 |
Primary Cell Phenotypic Screening Illuminates ADRs and AOPs
|
Bone, Audrey J.
|
|
2017
|
|
7 |
p. 781-782
2 p.
|
artikel
|
| 77 |
Principles of Chemical Biology: APEX, Cell-Free Enzyme Systems, New Antibiotics, Epigenetic-Membrane Relationship, and Metastable Transcription
|
|
|
2017
|
|
7 |
p. 773-774
2 p.
|
artikel
|
| 78 |
Privileged Electrophile Sensors: A Resource for Covalent Drug Development
|
Long, Marcus John Curtis
|
|
2017
|
|
7 |
p. 787-800
14 p.
|
artikel
|
| 79 |
Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities
|
Chen, Baoen
|
|
2018
|
|
7 |
p. 817-831
|
artikel
|
| 80 |
Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomics
|
White, Matthew E.H.
|
|
|
|
7 |
p. 828-838.e4
|
artikel
|
| 81 |
Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
|
Yan, Tianyang
|
|
|
|
7 |
p. 811-827.e7
|
artikel
|
| 82 |
Purine-ifying uric acid by gut microbes
|
Grelska, Agnieszka
|
|
|
|
7 |
p. 706-708
|
artikel
|
| 83 |
Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein
|
Plate, Lars
|
|
2019
|
|
7 |
p. 913-925.e4
|
artikel
|
| 84 |
Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo
|
To, Tsz-Leung
|
|
2016
|
|
7 |
p. 875-882
|
artikel
|
| 85 |
Redefining the Protein Kinase Conformational Space with Machine Learning
|
Ung, Peter Man-Un
|
|
2018
|
|
7 |
p. 916-924.e2
|
artikel
|
| 86 |
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors
|
Payne, N. Connor
|
|
|
|
7 |
p. 1140-1152.e5
|
artikel
|
| 87 |
Retraction Notice to: An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
|
Littlefield, Peter
|
|
2017
|
|
7 |
p. 917-
1 p.
|
artikel
|
| 88 |
ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
|
Sun, Rui
|
|
|
|
7 |
p. 739-752.e8
|
artikel
|
| 89 |
Sam68 Allows Selective Targeting of Human Cancer Stem Cells
|
Benoit, Yannick D.
|
|
2017
|
|
7 |
p. 833-844.e9
8.43999999168E11 p.
|
artikel
|
| 90 |
Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells
|
Fu, Kai
|
|
2017
|
|
7 |
p. 777-779
3 p.
|
artikel
|
| 91 |
Selective autophagy as the basis of autophagy-based degraders
|
Takahashi, Daiki
|
|
|
|
7 |
p. 1061-1071
|
artikel
|
| 92 |
Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia
|
She, Angela
|
|
2017
|
|
7 |
p. 892-906.e5
9.0599109E7 p.
|
artikel
|
| 93 |
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
|
Quinti, Luisa
|
|
2016
|
|
7 |
p. 849-861
|
artikel
|
| 94 |
Small molecules as tools for functional assessment of deubiquitinating enzyme function
|
Magin, Robert S.
|
|
|
|
7 |
p. 1090-1100
|
artikel
|
| 95 |
Small Molecules for Early Endosome-Specific Patch Clamping
|
Chen, Cheng-Chang
|
|
2017
|
|
7 |
p. 907-916.e4
9.159094E6 p.
|
artikel
|
| 96 |
Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization
|
McConnell, Scott A.
|
|
|
|
7 |
p. 726-738.e4
|
artikel
|
| 97 |
Spying on Cells: Toward a Perfect Sleeper Agent
|
Wiens, Matthew D.
|
|
2016
|
|
7 |
p. 756-758
|
artikel
|
| 98 |
Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities
|
Alyamani, Mohammad
|
|
2017
|
|
7 |
p. 825-832.e6
8.31999176E8 p.
|
artikel
|
| 99 |
Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase
|
Yanagisawa, Tatsuo
|
|
2019
|
|
7 |
p. 936-949.e13
|
artikel
|
| 100 |
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
|
Horton, John R.
|
|
2016
|
|
7 |
p. 769-781
|
artikel
|
| 101 |
Structural Basis for the Binding Selectivity of Human CDY Chromodomains
|
Dong, Cheng
|
|
|
|
7 |
p. 827-838.e7
|
artikel
|
| 102 |
Structural Insights into Subunits Assembly and the Oxyester Splicing Mechanism of Neq pol Split Intein
|
Gordo, Verónica
|
|
2018
|
|
7 |
p. 871-879.e2
|
artikel
|
| 103 |
Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA
|
Pyle, Euan
|
|
2018
|
|
7 |
p. 840-848.e4
|
artikel
|
| 104 |
Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
|
Schlott, Anja C.
|
|
2019
|
|
7 |
p. 991-1000.e7
|
artikel
|
| 105 |
Systematic Metrics Depicting Cell Death Kinetics
|
Li, Ying
|
|
2017
|
|
7 |
p. 785-786
2 p.
|
artikel
|
| 106 |
Tagging and Enriching Proteins Enables Cell-Specific Proteomics
|
Elliott, Thomas S.
|
|
2016
|
|
7 |
p. 805-815
|
artikel
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| 107 |
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