Digitale Bibliotheek
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                             127 gevonden resultaten
nr titel auteur tijdschrift jaar jaarg. afl. pagina('s) type
1 A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters Zdouc, Mitja M.

5 p. 733-739.e4
artikel
2 Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses Napolitano, Valeria

5 p. 774-784.e8
artikel
3 Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing Peiffer, Brandon J.
2019
5 p. 652-661.e4
artikel
4 Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila Jonson, Maria
2018
5 p. 595-610.e5
artikel
5 Aiming at Cancer In Vivo: Ferroptosis-Inducer Delivered by Nanoparticles Yi, Junmei
2019
5 p. 621-622
artikel
6 An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance Hosfelt, Jordan

5 p. 854-869.e9
artikel
7 Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics Sosio, Margherita
2018
5 p. 540-549.e4
artikel
8 A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress Geib, Elena
2016
5 p. 587-597
11 p.
artikel
9 A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity Alder, Arne

5 p. 840-853.e6
artikel
10 Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers Moreno, Angelo
2019
5 p. 634-644.e3
artikel
11 Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel Paatero, Anja O.
2016
5 p. 561-566
6 p.
artikel
12 A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA Inoyama, Daigo

5 p. 560-570.e10
artikel
13 A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome Omachi, Kohei
2018
5 p. 634-643.e4
artikel
14 A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility Sakin, Volkan
2017
5 p. 635-645.e5
6.4499366E7 p.
artikel
15 Biosynthesis and Activity of Prenylated FMN Cofactors Wang, Po-Hsiang
2018
5 p. 560-570.e6
artikel
16 BMPing Up Healing Capacity with FKBP12 Ligand Williams, Charles H.
2019
5 p. 619-620
artikel
17 Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway Ci, Yali

5 p. 527-539.e5
artikel
18 Cells Stiffen for Cytokines Newton, Richard
2018
5 p. 495-496
artikel
19 Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant Rosenberg Jr., Eric M.
2019
5 p. 662-673.e7
artikel
20 Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections Jin, Xueyang

5 p. 553-568.e7
artikel
21 Chemical approaches to unraveling the biology of mycobacteria Finin, Peter

5 p. 420-435
artikel
22 Chemical-Induced Naive Pluripotency Russell, Angela J.
2016
5 p. 532-534
3 p.
artikel
23 Chemical strategies to understand and manipulate host-pathogen interactions Wagner, Bridget K.

5 p. 711-712
artikel
24 Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries Moret, Nienke
2019
5 p. 765-777.e3
artikel
25 Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites Cestari, Igor
2016
5 p. 608-617
10 p.
artikel
26 Cisplatin Analogs Confer Protection against Cyanide Poisoning Nath, Anjali K.
2017
5 p. 565-575.e4
5.749436E6 p.
artikel
27 Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1 Persaud, Rosanne

5 p. 870-882.e11
artikel
28 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex Hoch, Dominic G.

5 p. 586-597.e12
artikel
29 Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate Ohtoyo, Mamoru
2016
5 p. 555-560
6 p.
artikel
30 Controlling Sulfuryl-Transfer Biology Cook, Ian
2016
5 p. 579-586
8 p.
artikel
31 Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents Stévenin, Virginie

5 p. 741-756
artikel
32 Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells Shimada, Kenichi
2018
5 p. 585-594.e7
artikel
33 Copying Life: Synthesis of an Enzymatically Active Mirror-Image DNA-Ligase Made of D-Amino Acids Weidmann, Joachim
2019
5 p. 645-651.e3
artikel
34 Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite Bruning, John M.
2019
5 p. 674-685.e6
artikel
35 Covalent Probe Finds Carboxylic Acid Jones, Alexander
2017
5 p. 537-539
3 p.
artikel
36 Covalent Protein Labeling at Glutamic Acids Martín-Gago, Pablo
2017
5 p. 589-597.e5
5.9699412E7 p.
artikel
37 Cracking the Nonribosomal Code Ackerley, David F.
2016
5 p. 535-537
3 p.
artikel
38 CRISPR Lights up In Situ Protein Evolution Kerek, Evan M.

5 p. 475-478
artikel
39 CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes White, Carl W.

5 p. 499-510.e7
artikel
40 Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements Chen, Hui

5 p. 598-609.e4
artikel
41 Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus Doran, Todd M.
2016
5 p. 618-628
11 p.
artikel
42 Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Chennamadhavuni, Divya
2018
5 p. 571-584.e8
artikel
43 Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance Zhan, Wenhu

5 p. 457-469.e11
artikel
44 Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting Wang, Hao
2017
5 p. 576-588.e6
5.87999425E8 p.
artikel
45 Efficient inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc Wang, Shuen-Shiuan

5 p. 699-710.e5
artikel
46 Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock Zhang, Tianli
2019
5 p. 686-698.e4
artikel
47 “Expand and Click”: A New Method for Labeling HIV-1 Envelope Glycoproteins Fernandez, Melissa V.
2017
5 p. 548-550
3 p.
artikel
48 FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication Yamane, Daisuke

5 p. 799-810.e4
artikel
49 Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity Qiu, Yanping

5 p. 675-685.e5
artikel
50 Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus Daher, Wassim

5 p. 910-924.e7
artikel
51 GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity Louie, Sharon M.
2016
5 p. 567-578
12 p.
artikel
52 HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells Xia, Leiming

5 p. 610-624.e5
artikel
53 How do you mend inactive tumor suppressor mutants? You glue them! Hata, Akiko

5 p. 585-587
artikel
54 HSP60 Takes a Hit: Inhibition of Mitochondrial Protein Folding Venkatesh, Sundararajan
2017
5 p. 543-545
3 p.
artikel
55 Human nuclear hormone receptor activity contributes to malaria parasite liver stage development Mittal, Nimisha

5 p. 486-498.e7
artikel
56 Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling Tang, Cong

5 p. 636-647.e5
artikel
57 Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling Li, Michael

5 p. 883-896.e5
artikel
58 Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism Babin, Brett M.

5 p. 897-909.e7
artikel
59 Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model Zhang, Yan
2019
5 p. 623-633.e9
artikel
60 Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine Hulce, Kaitlin R.

5 p. 785-798.e19
artikel
61 Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A McClary, Brandon
2017
5 p. 605-613.e5
6.1299396E7 p.
artikel
62 Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation Warrier, Thulasi

5 p. 716-729
artikel
63 Integrating complex host-pathogen immune environments into S. aureus vaccine studies Tsai, Chih-Ming

5 p. 730-740
artikel
64 In This Issue 2016
5 p. v-vi
nvt p.
artikel
65 Investigation of Penicillin Binding Protein (PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis Zhou, Yongjun
2019
5 p. 737-744.e4
artikel
66 It Takes Two to Regenerate: Optimizing Custom Wnt Surrogates Hansen, Simon

5 p. 473-475
artikel
67 Light-Activated Chemotaxis Dore, Timothy M.
2016
5 p. 531-532
2 p.
artikel
68 Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells Nakanishi, Hideyuki

5 p. 662-674.e5
artikel
69 Linking Nucleoporins, Mitosis, and Colon Cancer Wong, Richard W.
2016
5 p. 537-539
3 p.
artikel
70 Mirroring Life’s Building Blocks Meledin, Roman
2019
5 p. 616-619
artikel
71 Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome Deni, Ioanna

5 p. 470-485.e6
artikel
72 Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone Wiechmann, Katja
2017
5 p. 614-623.e6
6.22999387E8 p.
artikel
73 Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery Drawnel, Faye Marie
2017
5 p. 624-634.e3
633377 p.
artikel
74 Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii Wang, Jiefei
2019
5 p. 745-755.e7
artikel
75 Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial Paradela, Luciana S.

5 p. 711-721.e8
artikel
76 Multi-protein complexes as drug targets Gestwicki, Jason E.

5 p. 713-715
artikel
77 MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome Qiu, ZhiJun

5 p. 538-550.e7
artikel
78 Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer Wang, Li
2018
5 p. 619-633.e5
artikel
79 Of Tangerines, Asparagus, and Nonprotein Biomolecules 2016
5 p. 529-530
2 p.
artikel
80 One Enzyme, Three Metabolites: Shewanella algae Controls Siderophore Production via the Cellular Substrate Pool Rütschlin, Sina
2017
5 p. 598-604.e10
6.039999999403E12 p.
artikel
81 Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient Hövelmann, Felix
2016
5 p. 629-634
6 p.
artikel
82 Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection Papadopoulou, Virginie

5 p. 513-526.e5
artikel
83 Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions Griffin, Matthew E.

5 p. 436-456
artikel
84 Pharmacological Complementation Remedies an Inborn Error of Lipid Metabolism Hartley, Meredith D.

5 p. 551-559.e4
artikel
85 Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins Wei, Tongyao

5 p. 722-732.e8
artikel
86 Polynuclear Ruthenium Amines Inhibit K2P Channels via a “Finger in the Dam” Mechanism Pope, Lianne

5 p. 511-524.e4
artikel
87 Principles of Chemical Biology: From Antibiotic Resistance to RNA-Targeted Therapy via Autoxidation and Lipid Droplets 2017
5 p. 533-534
2 p.
artikel
88 Proteasome inhibitors: The next generation of antimalarial drugs? Rosenthal, Philip J.

5 p. 413-415
artikel
89 Rationalizing the Right Ratios Arp, Johannes
2017
5 p. 539-541
3 p.
artikel
90 Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry Bauman, Katherine D.
2019
5 p. 724-736.e7
artikel
91 Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery Simm, Jaak
2018
5 p. 611-618.e3
artikel
92 Respire or expire—precision killing of Helicobacter pylori by targeting complex I respiration Fansler, Ryan T.

5 p. 417-419
artikel
93 Restoring two tumor suppressor pathways with one PAWI Myers, Rebecca L.

5 p. 590-593
artikel
94 Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo Georgiev, George I.

5 p. 811-823.e7
artikel
95 Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death Poreba, Marcin
2017
5 p. 550-552
3 p.
artikel
96 Scratching the Surface: Resurfacing Proteins to Endow New Properties and Function Chapman, Alex M.
2016
5 p. 543-553
11 p.
artikel
97 Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors Lettl, Clara

5 p. 499-512.e5
artikel
98 Shining a Light on Alport Syndrome Hale, Lorna J.
2018
5 p. 497-498
artikel
99 Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones Ramadurgum, Prerana

5 p. 622-634.e6
artikel
100 Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase Wu, Xiaojun

5 p. 571-585.e6
artikel
101 Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies Jiang, Shibo

5 p. 757-773
artikel
102 Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness Cheng, Jiongjia

5 p. 625-635.e5
artikel
103 Small molecule targeting of biologically relevant RNA tertiary and quaternary structures Zafferani, Martina

5 p. 594-609
artikel
104 Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism Irani, Seema
2018
5 p. 519-529.e4
artikel
105 Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity Knoops, Bernard
2018
5 p. 550-559.e3
artikel
106 Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription Struntz, Nicholas B.
2019
5 p. 711-723.e14
artikel
107 Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 Berger, Benedict-Tilman

5 p. 686-698.e7
artikel
108 Synthesis and Degradation of Adenosine 5′-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases Amici, Adolfo
2017
5 p. 553-564.e4
5.639448E6 p.
artikel
109 Taming transcription factors with TRAFTACs Ng, Christine S.C.

5 p. 588-590
artikel
110 Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras Samarasinghe, Kusal T.G.

5 p. 648-661.e5
artikel
111 Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells Erdogan, Mutlu

5 p. 610-621.e5
artikel
112 Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors Sivakumaren, Sindhu Carmen

5 p. 525-537.e6
artikel
113 Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120 Richard, Jonathan

5 p. 540-552.e6
artikel
114 The Chemical Biology of Ferroptosis in the Central Nervous System Ratan, Rajiv R.

5 p. 479-498
artikel
115 The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome Mardirossian, Mario
2018
5 p. 530-539.e7
artikel
116 The Late Endosome and Its Lipid BMP Act as Gateways for Efficient Cytosolic Access of the Delivery Agent dfTAT and Its Macromolecular Cargos Erazo-Oliveras, Alfredo
2016
5 p. 598-607
10 p.
artikel
117 The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix Gundogdu, Mehmet
2018
5 p. 513-518.e4
artikel
118 The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance Murithi, James M.

5 p. 824-839.e6
artikel
119 The Structural Relationship between Iterative and Modular PKSs Keatinge-Clay, Adrian T.
2016
5 p. 540-542
3 p.
artikel
120 To PEGylate or Not To PEGylate Therapeutics? Maier, Keith E.
2019
5 p. 615-616
artikel
121 Tracing MYC Expression for Small Molecule Discovery Steinberger, Jutta
2019
5 p. 699-710.e6
artikel
122 Translocation of a Cell Surface Spliceosomal Complex Induces Alternative Splicing Events and Lymphoma Cell Necrosis Tonapi, Sonal S.
2019
5 p. 756-764.e6
artikel
123 Turning the Light On in the Phenotypic Drug Discovery Black Box Moffat, John G.
2017
5 p. 545-547
3 p.
artikel
124 Two Are Better Than One: Dual Targeting of Riboswitches by Metabolite Analogs Krajewski, Stefanie Sandra
2017
5 p. 535-537
3 p.
artikel
125 Uncovering the Cellular Target of Agelastatin A Park, Yongho
2017
5 p. 542-543
2 p.
artikel
126 Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases Li, Jun
2018
5 p. 499-512
artikel
127 Weaponizing the proteasome to overcome antimalarial drug resistance Xiao, Zhangping

5 p. 415-417
artikel
                             127 gevonden resultaten
 
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