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                             79 gevonden resultaten
nr titel auteur tijdschrift jaar jaarg. afl. pagina('s) type
1 Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity Řezníčková, Eva
 2019
 182 C p.
 artikel
2 A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: Synthesis, biological evaluation, and molecular modeling Zhang, Bingbing
 2019
 182 C p.
 artikel
3 β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis Chandrakar, Pragya
 2019
 182 C p.
 artikel
4 14- and 15-membered lactone macrolides and their analogues and hybrids: structure, molecular mechanism of action and biological activity Janas, Anna
 2019
 182 C p.
 artikel
5 An epidermal growth factor receptor-targeted and endoplasmic reticulum-localized organic photosensitizer toward photodynamic anticancer therapy Zhao, Xuan
 2019
 182 C p.
 artikel
6 An overview of recent progress in siderophore-antibiotic conjugates Kong, Huimin
 2019
 182 C p.
 artikel
7 Application of glycosylation in targeted drug delivery Chen, Fang
 2019
 182 C p.
 artikel
8 Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells Bozdag, Murat
 2019
 182 C p.
 artikel
9 Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity Esposito, Francesca
 2019
 182 C p.
 artikel
10 Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors Sang, Yali
 2019
 182 C p.
 artikel
11 Curcumin analogues and their hybrid molecules as multifunctional drugs Noureddin, Sawsan A.
 2019
 182 C p.
 artikel
12 Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities Kumar, Raj
 2019
 182 C p.
 artikel
13 De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus Leal, Emilse S.
 2019
 182 C p.
 artikel
14 Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity Zhong, Chao
 2019
 182 C p.
 artikel
15 Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo Wang, Liang-Liang
 2019
 182 C p.
 artikel
16 Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research Hodon, Jiri
 2019
 182 C p.
 artikel
17 Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism Zhang, Guiping
 2019
 182 C p.
 artikel
18 Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors Sever, Belgin
 2019
 182 C p.
 artikel
19 Design, synthesis and biological evaluation of 1-benzyl-5-oxopyrrolidine-2-carboximidamide derivatives as novel neuroprotective agents Zhang, Linkui
 2019
 182 C p.
 artikel
20 Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo Pang, Yanqing
 2019
 182 C p.
 artikel
21 Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents Li, Bing
 2019
 182 C p.
 artikel
22 Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers Teodori, Elisabetta
 2019
 182 C p.
 artikel
23 Design, synthesis of oleanolic acid-saccharide conjugates using click chemistry methodology and study of their anti-influenza activity Su, Yangqing
 2019
 182 C p.
 artikel
24 Developing a binuclear multi-target Bi(III) complex by optimizing 2-acetyl-3-ethylpyrazine thiosemicarbazides Khan, Muhammad Hamid
 2019
 182 C p.
 artikel
25 Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα Yin, Yong
 2019
 182 C p.
 artikel
26 Discovery and biological evaluation of darolutamide derivatives as inhibitors and down-regulators of wild-type AR and the mutants Yu, Jiang
 2019
 182 C p.
 artikel
27 Discovery and synthesis of 3- and 21-substituted fusidic acid derivatives as reversal agents of P-glycoprotein-mediated multidrug resistance Guo, Mengqi
 2019
 182 C p.
 artikel
28 Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists Zhu, Yan
 2019
 182 C p.
 artikel
29 Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain Lee, Hobin
 2019
 182 C p.
 artikel
30 Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation Xue, Yu
 2019
 182 C p.
 artikel
31 Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation Boraei, Ahmed T.A.
 2019
 182 C p.
 artikel
32 Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing Zhao, Tong
 2019
 182 C p.
 artikel
33 Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease Gutti, Gopichand
 2019
 182 C p.
 artikel
34 Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer Du, Qianming
 2019
 182 C p.
 artikel
35 Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2) Hussein, Buthaina
 2019
 182 C p.
 artikel
36 Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation Astolfi, Andrea
 2019
 182 C p.
 artikel
37 Discovery of tissue selective liver X receptor agonists for the treatment of atherosclerosis without causing hepatic lipogenesis Li, Chanjuan
 2019
 182 C p.
 artikel
38 Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins Chen, Deheng
 2019
 182 C p.
 artikel
39 Editorial Board 2019
 182 C p.
 artikel
40 Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work Kumar, Rajesh
 2019
 182 C p.
 artikel
41 From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction Kalinin, Stanislav
 2019
 182 C p.
 artikel
42 Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells Tan, Yu-Jia
 2019
 182 C p.
 artikel
43 Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment Fan, Hua-yang
 2019
 182 C p.
 artikel
44 Graphical abstract TOC 2019
 182 C p.
 artikel
45 Graphical abstract TOC 2019
 182 C p.
 artikel
46 Graphical abstract TOC continued 2019
 182 C p.
 artikel
47 Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism Luan, Zhi-Lin
 2019
 182 C p.
 artikel
48 Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction Neochoritis, Constantinos G.
 2019
 182 C p.
 artikel
49 Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL Yang, Lixin
 2019
 182 C p.
 artikel
50 Imidazo[2,1-a]isoindole scaffold as an uncharted structure active on Leishmania donovani Arsène, Sobinson
 2019
 182 C p.
 artikel
51 Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases Xi, Jianjun
 2019
 182 C p.
 artikel
52 Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology Menezes, José C.J.M.D.S.
 2019
 182 C p.
 artikel
53 Natural products as important tyrosine kinase inhibitors Yin, Bo
 2019
 182 C p.
 artikel
54 Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives Mahmoud, Walaa R.
 2019
 182 C p.
 artikel
55 Novel antiacanthamoebic compounds belonging to quinazolinones Anwar, Ayaz
 2019
 182 C p.
 artikel
56 Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displaying improved estrogen receptor α degradation activity Hu, Zhiye
 2019
 182 C p.
 artikel
57 Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib Radaram, Bhasker
 2019
 182 C p.
 artikel
58 Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease Lanthier, Caroline
 2019
 182 C p.
 artikel
59 Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies Ye, Jiqing
 2019
 182 C p.
 artikel
60 Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition Ribeiro, Amélia Galdino
 2019
 182 C p.
 artikel
61 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC Dokla, Eman M.E.
 2019
 182 C p.
 artikel
62 Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity Elsebaei, Mohamed M.
 2019
 182 C p.
 artikel
63 Practical approaches to evaluating and optimizing brain exposure in early drug discovery Freeman III, Burgess B.
 2019
 182 C p.
 artikel
64 Primaquine derivatives: Modifications of the terminal amino group Zorc, Branka
 2019
 182 C p.
 artikel
65 Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model Reddy, Velma Ganga
 2019
 182 C p.
 artikel
66 Recent advancements in mechanistic studies and structure activity relationship of FoF1 ATP synthase inhibitor as antimicrobial agent Narang, Rakesh
 2019
 182 C p.
 artikel
67 Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment Saquib, Mohammad
 2019
 182 C p.
 artikel
68 ROS-responsive fluorinated polycations as non-viral gene vectors Zhang, Ju-Hui
 2019
 182 C p.
 artikel
69 Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins Subedi, Yagya Prasad
 2019
 182 C p.
 artikel
70 STING modulators: Predictive significance in drug discovery Cui, Xiangling
 2019
 182 C p.
 artikel
71 Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation Moi, Davide
 2019
 182 C p.
 artikel
72 Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate Ke, Yu
 2019
 182 C p.
 artikel
73 Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors Moi, Davide
 2019
 182 C p.
 artikel
74 Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents Lu, Lixue
 2019
 182 C p.
 artikel
75 Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis Feder, Daniel
 2019
 182 C p.
 artikel
76 Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies Sánchez-Fernández, Elena M.
 2019
 182 C p.
 artikel
77 Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease Monteiro, M.E.
 2019
 182 C p.
 artikel
78 Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives Catalano, Raffaella
 2019
 182 C p.
 artikel
79 The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities Rajasekaran, Ganesan
 2019
 182 C p.
 artikel
                             79 gevonden resultaten
 
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