| nr |
titel |
auteur |
tijdschrift |
jaar |
jaarg. |
afl. |
pagina('s) |
type |
| 1 |
Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes 1 1 Abbreviations: dCK, deoxycytidine kinase; dTK, thymidine kinase; CdA, 2-chloro-2′-deoxyadenosine; araC, 1-β-D-arabinofuranosylcytosine; 3HdC, 2′-deoxy-[5-3H] cytidine; 3HdT, 2′-deoxy-[5-methyl-3H] thymidine; HL 60, human promyelocytic cell line; AML, acute myeloid leukaemia; PBMC, peripherial blood mononuclear cell; APC, aphidicolin; and DEAE, diethylaminoethyl.
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Csapó, Zsolt
|
|
2001
|
61 |
2 |
p. 191-197
7 p.
|
artikel
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| 2 |
Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor 1 1 Abbreviations: CCPA, 2-chloro-N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; CPA, N6-cyclopentyladenosine, R-PIA, N6-[-(R)-1-methyl-2-phenylethyl]adenosine; NECA, 5′-(N-ethyl)-carboxamidoadenosine; N-0840, N6-cyclopentyl-9-methyladenine; theophylline, 1,3-dimethylxanthine; PD81,723, (2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone; BCA, bicinchoninic acid; BCS, bovine calf serum; cAMP, adenosine 3′,5′-cyclic monophosphate; DMEM, Dulbecco’s modified Eagle’s medium; CHO, Chinese hamster ovary; and wt, wild-type.
|
Kourounakis, Angeliki
|
|
2001
|
61 |
2 |
p. 137-144
8 p.
|
artikel
|
| 3 |
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase 1 1 Abbreviations: BVdU, (E)-5-(2-bromovinyl)-2′-deoxyuridine; BVdUMP, (E)-5-(2-bromovinyl)-2′-deoxyuridine 5′-monophosphate; NB1011, (E)-5-(2-bromovinyl)-2′-deoxy-5′-uridyl phenyl l-methoxyalaninylphosphoramidate; COSY, correlated spectroscopy; DCI, direct current ionization; DMF, N,N-dimethylformamide; dUMP, 2′-deoxyuridine 5′-monophosphate; ECTA, enzyme-catalyzed therapeutic agent; 5-FU, 5-fluorouracil; 5-FdUMP, 5-fluoro-2′-deoxyuridine 5′-monophosphate; RFU, relative fluorescence units; THF, N 5,N 10-methylene tetrahydrofolate; TBDMS, tert-butyldimethylsilyl; and TS, thymidylate synthase (EC 2.1.1.45).
|
Lackey, David B.
|
|
2001
|
61 |
2 |
p. 179-189
11 p.
|
artikel
|
| 4 |
Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth 1 1 Abbreviations: AMA, S-(5′-deoxy-5′-adenosyl)-methylthioethyl-hydroxylamine; APA, 1-aminooxy-3-aminopropane; DFMO, alpha-difluoromethylornithine; DMEM, Dulbecco’s modified Eagle’s medium; DTT, dithiothreitol; EGF, epidermal growth factor; 5-FU, 5-fluorouracil; LDH, lactate dehydrogenase; MGBG, methyl-bisguanylhydrazone; SAM, S-adenosylmethionine; SAMDC, S-adenosylmethionine decarboxylase; and ODC, ornithine decarboxylase.
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Milovica, Vladan
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|
2001
|
61 |
2 |
p. 199-206
8 p.
|
artikel
|
| 5 |
Immunolocalisation of adenosine A1 receptors in the rat kidney
|
Smith, Jane A
|
|
2001
|
61 |
2 |
p. 237-244
8 p.
|
artikel
|
| 6 |
Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures 1 1 Abbreviations: Ah, aryl hydrocarbon; c/EBP, CCAAT/enhancer-binding protein; cDNA, complementary DNA CYP, cytochrome P450; EROD, ethoxyresorufin-O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSTA, glutathione S-transferase alpha; HNF, hepatic nuclear factor; RT–PCR, reverse transcription–polymerase chain reaction; and TF, transcription factor.
|
Borlak, Jürgen
|
|
2001
|
61 |
2 |
p. 145-153
9 p.
|
artikel
|
| 7 |
Inhibition of heart mitochondrial lipid peroxidation by non-toxic concentrations of carvedilol and its analog BM-910228 1 1 Abbreviations: TBARS, thiobarbituric acid-reactive substances; ROS, reactive oxygen species; TPP+, tetraphenylphosphonium ion; ΔΨ, mitochondrial membrane potential.
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Santos, Dario J.S.L
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|
2001
|
61 |
2 |
p. 155-164
10 p.
|
artikel
|
| 8 |
Inhibition of stimulated Jurkat cell adenosine 3′,5′-cyclic monophosphate synthesis by the immunomodulatory compound HR325 7 7 Abbreviations: PGE2, prostaglandin E2; FKN, forskolin; CTX, cholera toxin; cAMP, adenosine 3′,5′-cyclic monophosphate; IBMX, 3-isobutyl-1-methylxanthine; NCA, niclosamide; FCCP, carbonyl cyanide p-trifluoromethoxyphenyl hydrazone; DHO-DH, dihydroorotate dehydrogenase; IL-2, interleukin-2; and HBSS, Hanks’ balanced salt solution.
|
Curnock, Adam P.
|
|
2001
|
61 |
2 |
p. 227-235
9 p.
|
artikel
|
| 9 |
Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro 1 1 Abbreviations: BSO, l-buthionine sulphoximine; DNP-SG, S-2,4-dinitrophenylglutathione; DTT, dithiothreitol; GST, glutathione S-transferase; HL60, human leukaemia 60; JNK1, c-Jun N-terminal kinase 1; ML-1, human myeloblastic leukaemia-1; PEITC, phenethyl isothiocyanate; PETC, N-phenethylthiocarbamoyl; PETC-Cys, S-(N-phenethylthiocarbamoyl)cysteine; PETC-SG, S-(N-phenethylthiocarbamoyl)glutathione; and Z-VAD-fmk, N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone.
|
Xu, Ke
|
|
2001
|
61 |
2 |
p. 165-177
13 p.
|
artikel
|
| 10 |
Oxidative activation of indole-3-acetic acids to cytotoxic species— a potential new role for plant auxins in cancer therapy 1 1 Abbreviations: IAA, indole-3-acetic acid; HRP, horseradish peroxidase; TBA, thiobarbituric acid; MPO, myeloperoxidase; MOI, 3-methylene-2-oxindole; BSO, buthionine sulphoximine; GSH, glutathione; CEA, carcinoembryonic antigen; ADEPT, antibody directed enzyme prodrug therapy; PDEPT, polymer directed enzyme prodrug therapy; GDEPT, gene directed enzyme prodrug therapy; and PEG, polyethylene glycol.
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Folkes, Lisa K.
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|
2001
|
61 |
2 |
p. 129-136
8 p.
|
artikel
|
| 11 |
Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice
|
Srinivasan, Chandrika
|
|
2001
|
61 |
2 |
p. 245-252
8 p.
|
artikel
|
| 12 |
The polyamine stress response: tissue-, endocrine-, and developmental-dependent regulation 1 1 Abbreviations: PA, polyamine; PSR, polyamine stress response; HPA, hypothalamic–pituitary–adrenocortical; ODC, ornithine decarboxylase.
|
Gilad, Varda H.
|
|
2001
|
61 |
2 |
p. 207-213
7 p.
|
artikel
|
| 13 |
Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements 1 1 Abbreviations: EPRE, electrophile response element; AHRE, aromatic hydrocarbon response element; MRE, metal response element; Nqo1 and NQO1, mouse NAD(P)H:quinone oxidoreductase [also called NMO1, quinone reductase, DT-diaphorase] gene and mRNA; Cyp1a1 and CYP1A1, mouse cytochrome P450 1A1 gene and mRNA; Mt1 and MT1, mouse metallothionein-1 gene and mRNA; Sod, mouse Cu,Zn-superoxide dismutase gene; SOD, rat Cu,Zn-superoxide dismutase gene; SOD, mouse and rat Cu,Zn-superoxide dismutase mRNA and protein; Luc and LUC, firefly luciferase gene and enzyme; BGAL, β-galactosidase enzyme activity; tBHQ, tert-butylhydroquinone; dioxin (also TCDD), 2,3,7,8-tetrahydro chlorodibenzo-p-dioxin; SSC, standard sodium citrate; and SET, sodium ethylenediamine tetraacetic acid (EDTA) Tris buffer.
|
Dieter, Matthew Z
|
|
2001
|
61 |
2 |
p. 215-225
11 p.
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artikel
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