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| Titel: |
FTIR microscopy as a method for detection of retrovirally transformed cells |
| Auteur: |
Huleihel, Mahmoud Talyshinsky, Marina Erukhimovitch, Vitaly |
| Verschenen in: |
Spectroscopy |
| Paginering: | Jaargang 15 (2001) nr. 2 pagina's 57-64 |
| Jaar: |
2001-09-24 |
| Inhoud: |
Fourier transform infrared (FTIR) spectroscopy is a unique technique that has potential for the optical diagnosis of cellular variations based on the characteristic molecular vibrational spectra of the cells. In the present study, a refinement of this technique – FTIR microscopy – was used in a mouse model to investigate spectral differences between primary cells and malignant cells transformed by murine sarcoma virus (MuSV). The advantage of FTIR microscopy is that it facilitates inspection of a restricted region of cell growth on a slide. A significant decrease in the intensities of the spectra was seen in malignant cells transformed by MuSV compared to primary normal cells. Also, there was a significant shift in the PO-2 symmetric stretching mode from 1082 cm-1 for normal cells to 1086 cm-1 for malignant cells. Detectable and consistent differences between normal primary and malignant cells were evident in the shapes and positions of a number of peaks in the FTIR spectra. Our results indicated that FTIR microscopy has potential as a diagnostic method for the detection of malignant cells. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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