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Details van artikel 53 van 60 gevonden artikelen
| Titel: |
Spontaneous ARIA (Amyloid-Related Imaging Abnormalities) and Cerebral Amyloid Angiopathy Related Inflammation in Presenilin 1-Associated Familial Alzheimer's Disease |
| Auteur: |
Ryan, Natalie S. Lashley, Tammaryn Revesz, Tamas Dantu, Kiran Fox, Nick C. Morris, Huw R. |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 44 (2014) nr. 4 pagina's 1069-1074 |
| Jaar: |
2014-11-18 |
| Inhoud: |
Amyloid-related imaging abnormalities (ARIA), thought to reflect immune responses to vascular amyloid, have been detected in several amyloid-modifying therapy trials for Alzheimer's disease (AD). We report a case of ARIA developing spontaneously during the course of Presenilin 1 (PSEN1)-associated familial AD (FAD), in an APOE4 homozygous patient. Severe cerebral amyloid angiopathy with associated inflammation was subsequently found at autopsy. Recognition that ARIA may arise spontaneously during FAD and of the potential risk factors for its development are important observations given the recent launch of amyloid-modifying therapy trials for FAD. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 53 van 60 gevonden artikelen
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