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| Titel: |
Losartan-Induced Hypotension Leads to Tau Hyperphosphorylation and Memory Deficit |
| Auteur: |
Liu, Xinghua Wang, Zhihong Xia, Yiyuan Yu, Guang Zeng, Kuan Luo, Hongbin Hu, Jichang Gong, Cheng-Xin Wang, Jian-Zhi Zhou, Xin-Wen Wang, Xiao-Chuan |
| Verschenen in: |
Journal of Alzheimer's disease |
| Paginering: | Jaargang 40 (2014) nr. 2 pagina's 419-427 |
| Jaar: |
2014-01-21 |
| Inhoud: |
Recent studies have reported a correlation between dementia and low blood pressure. How hypotension is associated with the increased risk of Alzheimer's disease (AD) remains unclear. Here we show that one month treatment of losartan, an angiotensin II type 1 (AT1) receptor antagonist, causes chronic and sustained hypotension, along with oxidative stress in adult male Sprague-Dawley rats. Furthermore, we show that losartan treatment increases the level of inactivated protein phosphatase 2A (PP2A) and the hyperphosphorylation of tau at Ser 199 and Ser 396. Rats treated with losartan present memory deficits and decreases in spine-density. These findings suggest that losartan-induced hypotension may increase the risk of AD-like pathological alteration and behavioral impairment through oxidative stress which leads to tau hyperphosphorylation and loss of dendritic spines. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 14 van 25 gevonden artikelen
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