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| Titel: |
Mcl-1 expression is up-regulated in malignancies of the parotid gland |
| Auteur: |
Heiduschka, Gregor Erovic, Boban M. Pammer, Johannes Kotowski, Ulana Kaider, Alexandra Ch. Grasl, Matthaeus Thurnher, Dietmar |
| Verschenen in: |
Disease markers |
| Paginering: | Jaargang 30 (2011) nr. 5 pagina's 229-233 |
| Jaar: |
2011-07-01 |
| Inhoud: |
The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma. All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival. Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 23 van 38 gevonden artikelen
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