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Details van artikel 11 van 37 gevonden artikelen
| Titel: |
Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: Results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study |
| Auteur: |
M. Cristina Polidori Domenico Praticó Tiziana Ingegni Elena Mariani Liana Spazzafumo Paola Del Sindaco Roberta Cecchetti Yuemang Yao Stefano Ricci Antonio Cherubini Wilhelm Stahl Helmut Sies Umberto Senin Patrizia Mecocci |
| Verschenen in: |
BioFactors |
| Paginering: | Jaargang 24 (2006) nr. 1-4 pagina's 265-274 |
| Jaar: |
2006-01-16 |
| Inhoud: |
A condition of oxidative stress is known to occur in ischemic stroke, the current therapeutic intervention of which is largely limited to thrombolysis. To assess the effect of vitamin C - in conjunction to aspirin - in ischemic stroke-related lipid peroxidation, we measured plasma levels of ascorbate, of 8,12-isoprostanes F2α-VI (8,12-iPF2α-VI) and activities and levels of a broad spectrum of antioxidant enzymes and micronutrients in stroke patients randomized to receive, from stroke onset and up to three months, either vitamin C (200 mg/day) plus aspirin (300 mg/day) or only aspirin (300 mg/day). By the end of the first week, patients treated with vitamin C plus aspirin had higher vitamin C levels (p = 0.02) and lower 8,12-iPF2α-VI levels (p = 0.01) than patients treated with aspirin alone. The significance was maintained for the increase of vitamin C after three months of therapy (p < 0.01). The clinical functional outcome for both groups of patients similarly ameliorated after three months of treatment. We conclude that vitamin C, at the dose of 200~mg/day and in conjunction with aspirin, significantly decreases ischemic stroke-related lipid peroxidation in humans. Further studies are warranted to clarify whether the use of vitamin C may add clinical long-term beneficial effects in patients with stroke. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 11 van 37 gevonden artikelen
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