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| Titel: |
Proteomics approach for prediction of immunogenic site from Footand- mouth disease virus |
| Auteur: |
Gomase V.S. Phadnis A. C. Tripathi A.K. |
| Verschenen in: |
International journal of biotechnology applications |
| Paginering: | Jaargang 1 (2009) nr. 1 pagina's 01-03 |
| Jaar: |
2009 |
| Inhoud: |
Foot-and-mouth disease is caused by FMDV, an Aphthovirus of the viral familyPicornaviridae. Peptide fragments of Foot-and-mouth disease virus protein can be used to selectnonamers for use in rational vaccine design and to increase the understanding of roles of the immunesystem in infectious diseases. Analysis shows MHC class II binding peptides of protein from Footand-mouth disease virus are important determinant for protection of host form viral infection. In thisassay we predicted the binding affinity of protein having 213 amino acids, which shows nonamers.These peptides are from a set of aligned peptides known to bind to a given MHC molecule as thepredictor of MHC-peptide binding. MHCII molecules bind peptides in similar yet different modes andalignments of MHCII-ligands were obtained to be consistent with the binding mode of the peptides totheir MHC class, this means the increase in affinity of MHC binding peptides may result inenhancement of immunogenicity of protein nonamers. Binding ability prediction of antigen peptides tomajor histocompatibility complex (MHC) class I & II molecules is important in vaccine developmentfrom Foot-and-mouth disease virus. |
| Uitgever: |
Bioinfo Publications (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 5 gevonden artikelen
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